TY  - JOUR
AU  - Licher, Jörg
AU  - Achenbach, Julia
AU  - Köhn, Janett
AU  - Diefenhardt, Markus
AU  - Fleischmann, Maximilian
AU  - Rödel, Claus
AU  - Tselis, Nikolaos
AU  - Ramm, Ulla
AU  - Scherf, Christian
TI  - Advantages of 3D printed patient-individual moulds in brachytherapy for facial skin cancer.
JO  - Strahlentherapie und Onkologie
VL  - 201
IS  - 9
SN  - 0179-7158
CY  - Heidelberg
PB  - Springer Medizin
M1  - DKFZ-2025-00452
SP  - 940-952
PY  - 2025
N1  - 2025 Sep;201(9):940-952
AB  - Facial skin cancer of 42 elderly frail patients was treated with individualised 3D-printed mould applicators for high-dose-rate (HDR) brachytherapy. The dosimetric outcome was compared to conventionally manufactured individual moulds used before.Tumour-adapted HDR brachytherapy source paths were pre-planned and dosimetrically optimised in the brachytherapy treatment planning system (TPS) using computed tomography (CT) data and considered in the design of the patient-individual moulds. Dosimetric outcome for the planning target volumes and organs at risk were statistically evaluated and compared for pre-planning, final clinical treatment planning with TG-43 formalism and retrospective tissue, material and CT density related TG-186 calculations.Pre-planning allows reliable brachytherapy source paths design to achieve intended dosimetric clinical goals. The 3D-printed patient-specific moulds show a clear advantage in the dosimetric coverage of the target volume (improving D90 from 98.3
KW  - 3D printing (Other)
KW  - Brachytherapy (Other)
KW  - Individual moulds (Other)
KW  - Radiotherapy (Other)
KW  - Skin cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40009080
DO  - DOI:10.1007/s00066-025-02372-5
UR  - https://inrepo02.dkfz.de/record/299492
ER  -