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| Home > Publications database > The m6A demethylase FTO promotes C/EBPβ-LIP translation to perform oncogenic functions in breast cancer cells. > print |
| Home > Publications database > The m6A demethylase FTO promotes C/EBPβ-LIP translation to perform oncogenic functions in breast cancer cells. > print |
| 001 | 299504 | ||
| 005 | 20250821121532.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:40022434 |
| 024 | 7 | _ | |2 ISSN |a 0014-2956 |
| 024 | 7 | _ | |2 ISSN |a 0945-5795 |
| 024 | 7 | _ | |2 ISSN |a 1432-1033 |
| 024 | 7 | _ | |2 ISSN |a 1742-464X |
| 024 | 7 | _ | |2 ISSN |a 1742-4658 |
| 024 | 7 | _ | |2 doi |a 10.1111/febs.70033 |
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| 037 | _ | _ | |a DKFZ-2025-00462 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zuidhof, Hidde R |b 0 |
| 245 | _ | _ | |a The m6A demethylase FTO promotes C/EBPβ-LIP translation to perform oncogenic functions in breast cancer cells. |
| 260 | _ | _ | |a Oxford [u.a.] |b Wiley-Blackwell |c 2025 |
| 336 | 7 | _ | |2 DRIVER |a article |
| 336 | 7 | _ | |2 DataCite |a Output Types/Journal article |
| 336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1748247841_9008 |
| 336 | 7 | _ | |2 BibTeX |a ARTICLE |
| 336 | 7 | _ | |2 ORCID |a JOURNAL_ARTICLE |
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| 500 | _ | _ | |a 2025 May;292(10):2688-2709 |
| 520 | _ | _ | |a N6-methyladenosine (m6A) is a prevalent posttranscriptional mRNA modification involved in the regulation of transcript turnover, translation, and other aspects of RNA fate. The modification is mediated by multicomponent methyltransferase complexes (so-called writers) and is reversed through the action of the m6A-demethylases fat mass and obesity-associated (FTO) and alkB homolog 5 (ALKBH5) (so-called erasers). FTO promotes cell proliferation, colony formation and metastasis in models of triple-negative breast cancer (TNBC). However, little is known about genome-wide or specific downstream regulation by FTO. Here, we examined changes in the genome-wide transcriptome and translatome following FTO knockdown in TNBC cells. Unexpectedly, FTO knockdown had a limited effect on the translatome, while transcriptome analysis revealed that genes related to extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) are regulated through yet unidentified mechanisms. Differential translation of CEBPB mRNA into the C/EBPβ transcription factor isoform C/EBPβ-LIP is known to act in a pro-oncogenic manner in TNBC cells through regulation of EMT genes. Here we show that FTO is required for efficient C/EBPβ-LIP expression, suggesting that FTO has oncogenic functions through regulation of C/EBPβ-LIP. |
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| 650 | _ | 7 | |2 Other |a C/EBPβ |
| 650 | _ | 7 | |2 Other |a FTO |
| 650 | _ | 7 | |2 Other |a breast cancer |
| 650 | _ | 7 | |2 Other |a mRNA translation |
| 700 | 1 | _ | |a Müller, Christine |b 1 |
| 700 | 1 | _ | |a Kortman, Gertrud |b 2 |
| 700 | 1 | _ | |a Wardenaar, René |b 3 |
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| 700 | 1 | _ | |0 0000-0001-6318-7210 |a Calkhoven, Cornelis F |b 6 |
| 773 | _ | _ | |0 PERI:(DE-600)2172518-4 |a DOI:10.1111/febs.70033 |n 10 |p 2688-2709 |t The FEBS journal |v 292 |x 0014-2956 |y 2025 |
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