TY  - JOUR
AU  - Nieder, Carsten
AU  - Popp, Ilinca
AU  - Grosu, Anca-Ligia
TI  - External Validation of an Extended Prognostic Assessment Model in Patients With Brain Metastases from Small-cell Lung Cancer.
JO  - Cancer diagnosis & prognosis
VL  - 5
IS  - 2
SN  - 2732-7787
CY  - Kapandriti, Attiki, Greece
PB  - International Institute of Anticancer Research
M1  - DKFZ-2025-00472
SP  - 171-178
PY  - 2025
AB  - Recently, the small-cell lung cancer (SCLC) grade model for patients with brain metastases was developed by a Japanese group. It includes sex, performance status, number of brain metastases, primary tumor control and presence of extracranial metastases. The aim of the present study was to validate this prognostic score in a European cohort of patients.The retrospective validation study included 189 patients from two centers in Germany and Norway. Survival according to the SCLC grade score was evaluated. Additional prognostic factors were analyzed.Median survival was 7.5 months. The 3-tiered SCLC grade score based on the sum of adverse prognostic features was significantly associated with survival (p<0.001): A higher point sum resulted in shorter survival. However, in our validation cohort, age affected survival to the same degree as several parameters that were part of the score.This validation study supports the international applicability of the SCLC grade model. Age, which has also been identified as a relevant prognostic factor in other previous studies (including the SCLC Graded Prognostic Assessment), may deserve consideration when trying to optimize survival prediction. Given that different studies identified different age limits, e.g., 70 or 75 years, merged databases are needed to provide definitive conclusions.
KW  - Radiation therapy (Other)
KW  - brain metastases (Other)
KW  - prognostic factors (Other)
KW  - small cell lung cancer (Other)
KW  - stereotactic radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40034954
C2  - pmc:PMC11871855
DO  - DOI:DOI:10.21873/cdp.10427
UR  - https://inrepo02.dkfz.de/record/299514
ER  -