%0 Journal Article
%A Trommer, Simon
%A Müller, Jörg Andreas
%A Oertel, Michael
%A Ehret, Felix
%A Roohani, Siyer
%A Ha, Hai Minh
%A Ha, Quynh Ngo
%A Hering, Kathrin
%A Nägler, Franziska
%A Lange, Tim
%A Mäurer, Matthias
%A Weissmann, Thomas
%A Putz, Florian
%A Trommer, Maike
%A Baues, Christian
%A Dobiasch, Sophie
%A Waltenberger, Maria
%A Skripcak, Tomas
%A Vordermark, Dirk
%A Medenwald, Daniel
%T Tumor volume change at radiation boost planning to estimate the response to chemoradiotherapy in stage III unresectable NSCLC (TORCH): a multicenter retrospective observational study.
%J Strahlentherapie und Onkologie
%V nn
%@ 0179-7158
%C Heidelberg
%I Springer Medizin
%M DKFZ-2025-00476
%P nn
%D 2025
%Z epub
%X Progression-free (PFS) and overall survival (OS) in UICC stage III non-small cell lung cancer (NSCLC) after definitive concurrent chemoradiotherapy (CRT) can be increased with consolidating immunotherapy. Recent studies have shown a strong predictive value of gross tumor volume (GTV) changes during CRT on OS. The TORCH trial investigated the prognostic impact of GTV changes during CRT as a predictor for a response to immunotherapy.This retrospective non-interventional observational multicenter trial included n = 203 patients from 10 German university centers for radiation oncology with confirmed inoperable NSCLC in UICC stage III A-C. Patients had received CRT between 2015 and 2023 as a curative-intent treatment approach. Patient and tumor characteristics were collected anonymously via electronic case report forms. Initial GTVs before CRT (initial planning CT, GTV1) and at 40-50 Gy (re-planning CT for radiation boost, GTV2) were delineated. Absolute and relative GTV changes before/during CRT were correlated with OS to predict the response to CRT with sequential immunotherapy. Hazard ratios (HR) of survival analyses were estimated using adjusted Cox regression models.The mean GTV1 before radiation therapy (RT) was 145.29 ml with the 25th, 50th, and 75th percentiles being 61.36 ml, 145.29 ml, and 204.93 ml, respectively. Before initiation of the radiation boost, the mean GTV2 was 99.58 ml, with the 25th, 50th, and 75th percentiles at 32.93 ml, 70.45 ml, and 126.85 ml. The HR for the impact of GTV1 on survival was 0.99 per ml (95
%K Durvalumab (Other)
%K Gross tumor volume (Other)
%K Immunotherapy (Other)
%K Non-small cell lung cancer (Other)
%K Stage III lung cancer (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40029351
%R 10.1007/s00066-025-02374-3
%U https://inrepo02.dkfz.de/record/299518