%0 Journal Article
%A Höffmann, Laura
%A Blei, Magdalena
%A Reissig, Falco
%A Kopka, Klaus
%A Mamat, Constantin
%T Preparation of Macrobicyclic Cryptands for Radiometal Complexation: Preparation of Macropa-Based Cryptands for Efficient Complexation of Radiometals.
%J Journal of labelled compounds and radiopharmaceuticals
%V 68
%N 3
%@ 0022-2135
%C New York, NY [u.a.]
%I Wiley
%M DKFZ-2025-00485
%P e4136
%D 2025
%X Macrobicyclic cryptands and especially derivatives with functionalized side arms (picolinate, pyrimidine carboxylate, and bipyridine carboxylate) are able to complex metal ions effectively. In this regard, four new functionalized cryptands were prepared in a convenient two-step synthesis procedure starting from basic compound 4,10,16,22,27-pentaoxa-1,7,13,19-tetraazabicyclo[11.11.5]nonacosane and fully characterized. Their complexation behavior was tested via 1H NMR titration with Ba2+, Sc3+, La3+, Lu3+, In3+, and Pb2+ pointing out log K values between 1.4 and 4.0. Radiolabeling with selected cations of radiopharmaceutical relevance (131Ba, 225Ac, and 133La) was performed.
%K Radiopharmaceuticals: chemistry
%K Radiopharmaceuticals: chemical synthesis
%K NMR titration (Other)
%K cryptands (Other)
%K radiolabeling (Other)
%K stability (Other)
%K Radiopharmaceuticals (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40040466
%2 pmc:PMC11880877
%R 10.1002/jlcr.4136
%U https://inrepo02.dkfz.de/record/299527