TY  - JOUR
AU  - Höffmann, Laura
AU  - Blei, Magdalena
AU  - Reissig, Falco
AU  - Kopka, Klaus
AU  - Mamat, Constantin
TI  - Preparation of Macrobicyclic Cryptands for Radiometal Complexation: Preparation of Macropa-Based Cryptands for Efficient Complexation of Radiometals.
JO  - Journal of labelled compounds and radiopharmaceuticals
VL  - 68
IS  - 3
SN  - 0022-2135
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - DKFZ-2025-00485
SP  - e4136
PY  - 2025
AB  - Macrobicyclic cryptands and especially derivatives with functionalized side arms (picolinate, pyrimidine carboxylate, and bipyridine carboxylate) are able to complex metal ions effectively. In this regard, four new functionalized cryptands were prepared in a convenient two-step synthesis procedure starting from basic compound 4,10,16,22,27-pentaoxa-1,7,13,19-tetraazabicyclo[11.11.5]nonacosane and fully characterized. Their complexation behavior was tested via 1H NMR titration with Ba2+, Sc3+, La3+, Lu3+, In3+, and Pb2+ pointing out log K values between 1.4 and 4.0. Radiolabeling with selected cations of radiopharmaceutical relevance (131Ba, 225Ac, and 133La) was performed.
KW  - Radiopharmaceuticals: chemistry
KW  - Radiopharmaceuticals: chemical synthesis
KW  - NMR titration (Other)
KW  - cryptands (Other)
KW  - radiolabeling (Other)
KW  - stability (Other)
KW  - Radiopharmaceuticals (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40040466
C2  - pmc:PMC11880877
DO  - DOI:10.1002/jlcr.4136
UR  - https://inrepo02.dkfz.de/record/299527
ER  -