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@ARTICLE{Rauschenbach:299548,
      author       = {L. Rauschenbach$^*$ and F. M. Gerach$^*$ and C. Berliner
                      and T. Blau and S. Kebir$^*$ and C. Dobersalske$^*$ and C.
                      Deuschl and U. Sure and K. Herrmann and P. Dammann},
      title        = {[68{G}a]‑{DOTA}‑conjugated somatostatin
                      receptor‑targeting peptide {PET} for the differentiation
                      between meningioma and glioblastoma: {A} case report and
                      review of the literature.},
      journal      = {Oncology letters},
      volume       = {29},
      number       = {4},
      issn         = {1792-1074},
      address      = {Athens},
      publisher    = {Spandidos Publ.},
      reportid     = {DKFZ-2025-00492},
      pages        = {199},
      year         = {2025},
      note         = {2025 Feb 24;29(4):199},
      abstract     = {[68Ga]-tetraazacyclododecanetetraacetic acid
                      (DOTA)-conjugated positron emission tomography (PET) is
                      widely used to identify meningiomas due to their high
                      expression of somatostatin receptor type 2 (SSTR2). However,
                      recent evidence suggests that this tracer may also show
                      uptake in high-grade gliomas, raising concerns about its
                      diagnostic specificity. The current study presents a
                      challenging case of a 56-year-old man who was initially
                      diagnosed with a right temporal glioblastoma. Follow-up
                      imaging revealed a local recurrence and a new extra-axial
                      lesion suggestive of meningioma on magnetic resonance
                      imaging and [68Ga]-DOTA-octreotide (DOTATOC) PET.
                      Unexpectedly, histopathological analysis following resection
                      confirmed both lesions as glioblastomas, indicating that
                      SSTR2 uptake is not exclusive to meningiomas. A systematic
                      literature review further supports the fact that high-grade
                      gliomas can exhibit [68Ga]-DOTA tracer uptake, though
                      generally at lower levels than meningiomas. These findings
                      suggest that while [68Ga]-DOTA PET provides useful
                      diagnostic information, interpreting results requires
                      caution in cases where glioblastoma might mimic meningioma.
                      Future research should focus on establishing clear
                      thresholds to reliably distinguish between meningiomas and
                      high-grade gliomas, enhancing diagnostic precision and
                      treatment planning in neuro-oncology.},
      keywords     = {DOTA (Other) / glioblastoma (Other) / glioma (Other) /
                      positron emission tomography (Other) / somatostatin receptor
                      (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40052066},
      pmc          = {pmc:PMC11883336},
      doi          = {10.3892/ol.2025.14945},
      url          = {https://inrepo02.dkfz.de/record/299548},
}