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@ARTICLE{HuarocMoquillaza:299555,
      author       = {E. Huaroc Moquillaza and K. Weiss and L. Steinhelfer and J.
                      Stelter and M. R. Makowski and R. Braren$^*$ and M. Doneva
                      and D. C. Karampinos},
      title        = {{W}hole pancreas water {T}1 mapping at 3 {T}esla.},
      journal      = {Magnetic resonance materials in physics, biology and
                      medicine},
      volume       = {38},
      number       = {2},
      issn         = {0968-5243},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2025-00499},
      pages        = {271-283},
      year         = {2025},
      note         = {2025 Apr;38(2):271-283},
      abstract     = {A fast T1 mapping method of the whole pancreas remains a
                      challenge, due to the complex anatomy of the organ. In
                      addition, a technique for pancreas water T1 mapping is
                      needed, since the T1 is biased in the presence of fat. The
                      purpose of this work is to accelerate the acquisition of
                      water selective T1 (wT1) mapping for the whole pancreas at 3
                      T.The proposed method combines a continuous
                      inversion-recovery Look-Locker acquisition with a
                      single-shot gradient echo spiral readout, water-fat
                      separation and dictionary matching for wT1 mapping of the
                      whole pancreas at 3 T. The bias of T1 in the presence of fat
                      was evaluated in a phantom by comparing the modified
                      Look-Locker inversion-recovery (MOLLI) and the proposed
                      method to MRS measurements. The present method was validated
                      in 11 volunteers by evaluating its pancreas coverage and
                      repeatability and by comparing it to MOLLI. Four
                      pancreatitis patients were evaluated using the proposed
                      method and clinical scans.The phantom wT1 results are in
                      better agreement to MRS ( wT 1 = 1.02 *wT 1 MRS - 47.81 , R
                      2 = 0.99 ) than MOLLI ( T 1 MOLLI = 1.13 ∗ wT 1 MRS -
                      74.65 , R 2 = 0.98 ) . The volunteer wT1 results demonstrate
                      the whole pancreas coverage capability for different fat
                      fractions, good repeatability ( wT 1 , 2 ∘ = 0.98 ∗ wT 1
                      , 1 ∘ + 17.40 , R 2 = 0.69 ) and lower T1 values than
                      MOLLI ( wT 1 = 0.34 *T 1 MOLLI + 383.65 , R 2 = 0.26 ) . The
                      wT1 maps in patients captured diverse pancreatitis regions
                      with higher values ( wT 1 Patients = 831 - 1696 ms ) than in
                      the volunteers wT 1 Volunteers = 605 - 799 ms , thus showing
                      their potential clinical feasibility.The present work
                      proposes a wT1 mapping methodology of the whole pancreas at
                      3 T, where 24 slices ( 2 × 2 × 5 mm 3 ) were acquired in
                      three short breath-holds of 12 s each.},
      keywords     = {Dictionary matching (Other) / Look-Locker method (Other) /
                      Pancreas water T1 mapping (Other) / Spiral trajectory
                      (Other) / Whole pancreas (Other)},
      cin          = {MU01},
      ddc          = {530},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40048132},
      doi          = {10.1007/s10334-025-01224-8},
      url          = {https://inrepo02.dkfz.de/record/299555},
}