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000299563 1001_ $$00000-0001-7788-4914$$aMacarrón-Palacios, Victor$$b0
000299563 245__ $$aParalemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton.
000299563 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2025
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000299563 520__ $$aThe submembrane cytoskeleton of neurons displays a highly ordered 190-nanometer periodic actin-spectrin lattice, the membrane-associated periodic skeleton (MPS). It is involved in mechanical resilience, signaling, and action potential transmission. Here, we identify paralemmin-1 (Palm1) as a component and regulator of the MPS. Palm1 binds to the amino-terminal region of βII-spectrin, and MINFLUX microscopy localizes it in close proximity (<20 nanometers) to the actin-capping protein and MPS component adducin. Combining overexpression, knockout, and rescue experiments, we observe that the expression level of Palm1 controls the degree of periodicity of the MPS and also affects the electrophysiological properties of neurons. A single amino acid mutation (W54A) in Palm1 abolishes the MPS binding and remodeling activities of Palm1. Our findings identify Palm1 as a protein specifically dedicated to organizing the MPS and will advance the understanding of the assembly and plasticity of the actin-spectrin submembrane skeleton in general.
000299563 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
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000299563 650_7 $$012634-43-4$$2NLM Chemicals$$aSpectrin
000299563 650_7 $$2NLM Chemicals$$aActins
000299563 650_7 $$2NLM Chemicals$$aCytoskeletal Proteins
000299563 650_2 $$2MeSH$$aNeurons: metabolism
000299563 650_2 $$2MeSH$$aNeurons: cytology
000299563 650_2 $$2MeSH$$aCytoskeleton: metabolism
000299563 650_2 $$2MeSH$$aAnimals
000299563 650_2 $$2MeSH$$aProtein Binding
000299563 650_2 $$2MeSH$$aHumans
000299563 650_2 $$2MeSH$$aSpectrin: metabolism
000299563 650_2 $$2MeSH$$aSpectrin: genetics
000299563 650_2 $$2MeSH$$aActins: metabolism
000299563 650_2 $$2MeSH$$aCell Membrane: metabolism
000299563 650_2 $$2MeSH$$aCytoskeletal Proteins: metabolism
000299563 650_2 $$2MeSH$$aCytoskeletal Proteins: genetics
000299563 650_2 $$2MeSH$$aMice
000299563 7001_ $$00000-0003-0718-0895$$aHubrich, Jasmine$$b1
000299563 7001_ $$ado Rego Barros Fernandes Lima, Maria Augusta$$b2
000299563 7001_ $$00009-0003-6106-0728$$aMetzendorf, Nicole G$$b3
000299563 7001_ $$aKneilmann, Simon$$b4
000299563 7001_ $$0P:(DE-He78)7febcb2f4385ed4b379f34d11954e8e7$$aTrapp, Marleen$$b5$$udkfz
000299563 7001_ $$aAcuna, Claudio$$b6
000299563 7001_ $$0P:(DE-He78)7de884e25564c58f26d5c8dbed578256$$aPatrizi, Annarita$$b7$$udkfz
000299563 7001_ $$00000-0003-0781-187X$$aD'Este, Elisa$$b8
000299563 7001_ $$00000-0002-3536-5814$$aKilimann, Manfred W$$b9
000299563 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.adt3724$$gVol. 11, no. 10, p. eadt3724$$n10$$peadt3724$$tScience advances$$v11$$x2375-2548$$y2025
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