TY  - JOUR
AU  - Salviano-Silva, Amanda
AU  - Wollmann, Kathrin
AU  - Brenna, Santra
AU  - Reimer, Rudolph
AU  - Neumann, Julia E
AU  - Dottermusch, Matthias
AU  - Woythe, Laura
AU  - Maire, Cecile L
AU  - Puig, Berta
AU  - Schüller, Ulrich
AU  - Saul, Meike J
AU  - Westphal, Manfred
AU  - Drexler, Richard
AU  - Dührsen, Lasse
AU  - Gempt, Jens
AU  - Heiland, Dieter H
AU  - Lamszus, Katrin
AU  - Ricklefs, Franz L
TI  - Extracellular Vesicles Carrying Tenascin-C are Clinical Biomarkers and Improve Tumor-Derived DNA Analysis in Glioblastoma Patients.
JO  - ACS nano
VL  - 19
IS  - 10
SN  - 1936-0851
CY  - Washington, DC
PB  - Soc.
M1  - DKFZ-2025-00522
SP  - 9844-9859
PY  - 2025
N1  - 2025 Mar 18;19(10):9844-9859
AB  - Extracellular vesicles (EVs) act as carriers of biological information from tumors to the bloodstream, enabling the detection of circulating tumor material and tracking of disease progression. This is particularly crucial in glioblastoma, a highly aggressive and heterogeneous tumor that is challenging to monitor. Using imaging flow cytometry (IFCM), we conducted an immunophenotyping analysis of eight glioma-associated antigens and tetraspanins in plasma EVs from 37 newly diagnosed glioblastoma patients (pre- and post-surgery), 11 matched individuals with recurrent glioblastoma, and 22 healthy donors (HD). Tenascin-C (TNC) positive EVs displayed the strongest differences in newly diagnosed and recurrent glioblastoma patients, when compared to non-tumor subjects. Among dual-positive subpopulations, TNC+/CD9+ EVs were the most elevated in newly diagnosed (FC = 7.6, p <0.0001, AUC = 81
KW  - Tenascin-C (Other)
KW  - biomarkers (Other)
KW  - extracellular vesicles (Other)
KW  - glioblastoma (Other)
KW  - liquid biopsy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40056466
DO  - DOI:10.1021/acsnano.4c13599
UR  - https://inrepo02.dkfz.de/record/299581
ER  -