%0 Journal Article
%A Rimner, Andreas
%A Dejonckheere, Cas Stefaan
%A Sahlmann, Jörg
%A Barth, Simeon Ari
%A Schimek-Jasch, Tanja
%A Adebahr, Sonja
%A Hecht, Markus
%A Waller, Cornelius F
%A Schmid, Severin
%A Stolz, Daiana
%A Miederer, Matthias
%A Brose, Alexander
%A Binder, Harald
%A König, Jochem
%A Grosu, Anca-Ligia
%A Nestle, Ursula
%A Gkika, Eleni
%T Impact of Different Mediastinal Staging Modalities on Target Volume Delineation in Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the Multicenter Randomized PET-Plan Trial.
%J International journal of radiation oncology, biology, physics
%V 122
%N 5
%@ 0360-3016
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-00525
%P 1217-1226
%D 2025
%Z Volume 122, Issue 5, 1 August 2025, Pages 1217-1226
%X To evaluate the role of different invasive and non-invasive mediastinal staging methods in patients with locally advanced non-small-cell lung cancer (NSCLC) treated with definitive chemoradiotherapy in the prospective XXX trial (XXX; NCTXXX) and to evaluate the impact of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy on target volume definition.Patients treated per-protocol (n = 172), all receiving isotoxically dose-escalated chemoradiotherapy, were included in this unplanned secondary analysis. Radiation treatment planning was based on an 18F-FDG PET/CT targeting all CT positive lymph nodes (i.e. short axis diameter > 10 mm), even if PET-negative, plus elective nodal irradiation (arm A) or targeting only PET-positive nodes (arm B). The concordance rate between different staging modalities and their impact on target volume delineation were calculated.The median follow-up time (95
%K (18)F-FDG PET/CT (Other)
%K definitive chemoradiotherapy (Other)
%K endobronchial ultrasound (Other)
%K mediastinoscopy (Other)
%K non-small-cell lung cancer (Other)
%K staging (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40054586
%R 10.1016/j.ijrobp.2025.02.041
%U https://inrepo02.dkfz.de/record/299584