TY  - JOUR
AU  - Rimner, Andreas
AU  - Dejonckheere, Cas Stefaan
AU  - Sahlmann, Jörg
AU  - Barth, Simeon Ari
AU  - Schimek-Jasch, Tanja
AU  - Adebahr, Sonja
AU  - Hecht, Markus
AU  - Waller, Cornelius F
AU  - Schmid, Severin
AU  - Stolz, Daiana
AU  - Miederer, Matthias
AU  - Brose, Alexander
AU  - Binder, Harald
AU  - König, Jochem
AU  - Grosu, Anca-Ligia
AU  - Nestle, Ursula
AU  - Gkika, Eleni
TI  - Impact of Different Mediastinal Staging Modalities on Target Volume Delineation in Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the Multicenter Randomized PET-Plan Trial.
JO  - International journal of radiation oncology, biology, physics
VL  - 122
IS  - 5
SN  - 0360-3016
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-00525
SP  - 1217-1226
PY  - 2025
N1  - Volume 122, Issue 5, 1 August 2025, Pages 1217-1226
AB  - To evaluate the role of different invasive and non-invasive mediastinal staging methods in patients with locally advanced non-small-cell lung cancer (NSCLC) treated with definitive chemoradiotherapy in the prospective XXX trial (XXX; NCTXXX) and to evaluate the impact of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy on target volume definition.Patients treated per-protocol (n = 172), all receiving isotoxically dose-escalated chemoradiotherapy, were included in this unplanned secondary analysis. Radiation treatment planning was based on an 18F-FDG PET/CT targeting all CT positive lymph nodes (i.e. short axis diameter > 10 mm), even if PET-negative, plus elective nodal irradiation (arm A) or targeting only PET-positive nodes (arm B). The concordance rate between different staging modalities and their impact on target volume delineation were calculated.The median follow-up time (95
KW  - (18)F-FDG PET/CT (Other)
KW  - definitive chemoradiotherapy (Other)
KW  - endobronchial ultrasound (Other)
KW  - mediastinoscopy (Other)
KW  - non-small-cell lung cancer (Other)
KW  - staging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40054586
DO  - DOI:10.1016/j.ijrobp.2025.02.041
UR  - https://inrepo02.dkfz.de/record/299584
ER  -