TY  - JOUR
AU  - Gambichler, Thilo
AU  - Girke, Sophia
AU  - Abu Rached, Nessr
AU  - Susok, Laura
AU  - Becker, Jürgen
AU  - Schulze, Hans-Joachim
AU  - Hirsch, Tobias
AU  - Kückelhaus, Maximilian
AU  - Wellenbrock, Sascha
TI  - Low Intratumoral CD200 Protein Expression in Primary Merkel Cell Carcinoma Is a Strong Predictor for Disease Relapse.
JO  - Cancers
VL  - 17
IS  - 5
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-00539
SP  - 822
PY  - 2025
AB  - Merkel cell carcinoma (MCC) is a rare and frequently fatal form of skin cancer. Apart from Programmed Cell Death Protein 1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling, there is a lack of knowledge regarding other immune checkpoint molecules. Recent studies have observed elevated glycoprotein CD200 (also known as OX-2) mRNA expression in in different types of tumors, with CD200R-expressing myeloid cells present in the tumor microenvironment. However, the potential role of the CD200/CD200 axis as an additional checkpoint modulator remains widely unexplored. The aim of this study was to determine the intratumoral protein expression of CD200 as well as CD200R in a larger cohort of MCC patients and to correlate the expression levels with patients' outcomes.In this multicenter study, we investigated 68 patients with MCC (68 primary tumors and 15 corresponding metastases). Immunohistochemistry (IHC) was performed for CD200 as well as CD200R. Digital quantification and analysis of IHC were performed using QuPath-0.2.3.CD200 and CD200R expression was observed in 100
KW  - CD200/CC200R-signaling (Other)
KW  - Merkel cell carcinoma (Other)
KW  - OX-2 (Other)
KW  - immune checkpoints (Other)
KW  - immunotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40075669
DO  - DOI:10.3390/cancers17050822
UR  - https://inrepo02.dkfz.de/record/299784
ER  -