%0 Journal Article
%A Mateos, Marion K
%A Ajuyah, Pamela
%A Fuentes-Bolanos, Noemi
%A El-Kamand, Sam
%A Barahona, Paulette
%A Altekoester, Ann-Kristin
%A Mayoh, Chelsea
%A Holliday, Holly
%A Liu, Jie
%A Cui, Louise
%A Pfaff, Elke
%A Mackay, Alan
%A Resnick, Adam C
%A Pinese, Mark
%A Lau, Loretta M S
%A Khuong-Quang, Dong-Anh
%A Dias, Kimberly
%A Goudie, Catherine
%A Salkeld, Alison
%A Rokita, Jo Lynne
%A Jones, David T W
%A Juretic, Nikoleta
%A Hayden, Elisha
%A Pfister, Stefan M
%A Kramm, Christof M
%A Blattner-Johnson, Mirjam
%A Jabado, Nada
%A Tsoli, Maria
%A Vittorio, Orazio
%A Mueller, Sabine
%A Guo, Yiran
%A Tucker, Katherine
%A Waszak, Sebastian M
%A Perreault, Sebastien
%A Jones, Chris
%A Wong-Erasmus, Marie
%A Cowley, Mark J
%A Ziegler, David S
%T Germline analysis of an international cohort of pediatric diffuse midline glioma patients.
%J Neuro-Oncology
%V 27
%N 7
%@ 1522-8517
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2025-00544
%P 1849-1863
%D 2025
%Z 2025 Sep 8;27(7):1849-1863
%X Factors that drive the development of diffuse midline gliomas (DMG) are unknown. Our study aimed to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in pediatric patients with DMG.We assembled an international cohort of 252 pediatric patients with DMG, including diffuse intrinsic pontine glioma (n=153), with germline whole genome or whole exome sequencing.We identified P/LP germline variants in cancer predisposition genes in 7.5
%K PARP inhibitor (Other)
%K diffuse midline glioma (Other)
%K germline variants (Other)
%K homologous recombination (Other)
%K pediatric (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40072012
%R 10.1093/neuonc/noaf061
%U https://inrepo02.dkfz.de/record/299789