TY  - JOUR
AU  - Mateos, Marion K
AU  - Ajuyah, Pamela
AU  - Fuentes-Bolanos, Noemi
AU  - El-Kamand, Sam
AU  - Barahona, Paulette
AU  - Altekoester, Ann-Kristin
AU  - Mayoh, Chelsea
AU  - Holliday, Holly
AU  - Liu, Jie
AU  - Cui, Louise
AU  - Pfaff, Elke
AU  - Mackay, Alan
AU  - Resnick, Adam C
AU  - Pinese, Mark
AU  - Lau, Loretta M S
AU  - Khuong-Quang, Dong-Anh
AU  - Dias, Kimberly
AU  - Goudie, Catherine
AU  - Salkeld, Alison
AU  - Rokita, Jo Lynne
AU  - Jones, David T W
AU  - Juretic, Nikoleta
AU  - Hayden, Elisha
AU  - Pfister, Stefan M
AU  - Kramm, Christof M
AU  - Blattner-Johnson, Mirjam
AU  - Jabado, Nada
AU  - Tsoli, Maria
AU  - Vittorio, Orazio
AU  - Mueller, Sabine
AU  - Guo, Yiran
AU  - Tucker, Katherine
AU  - Waszak, Sebastian M
AU  - Perreault, Sebastien
AU  - Jones, Chris
AU  - Wong-Erasmus, Marie
AU  - Cowley, Mark J
AU  - Ziegler, David S
TI  - Germline analysis of an international cohort of pediatric diffuse midline glioma patients.
JO  - Neuro-Oncology
VL  - 27
IS  - 7
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2025-00544
SP  - 1849-1863
PY  - 2025
N1  - 2025 Sep 8;27(7):1849-1863
AB  - Factors that drive the development of diffuse midline gliomas (DMG) are unknown. Our study aimed to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in pediatric patients with DMG.We assembled an international cohort of 252 pediatric patients with DMG, including diffuse intrinsic pontine glioma (n=153), with germline whole genome or whole exome sequencing.We identified P/LP germline variants in cancer predisposition genes in 7.5
KW  - PARP inhibitor (Other)
KW  - diffuse midline glioma (Other)
KW  - germline variants (Other)
KW  - homologous recombination (Other)
KW  - pediatric (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40072012
DO  - DOI:10.1093/neuonc/noaf061
UR  - https://inrepo02.dkfz.de/record/299789
ER  -