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000299791 1001_ $$aGabele, Anna$$b0
000299791 245__ $$aUnveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions.
000299791 260__ $$aMaryland Heights, MO$$bCell Press$$c2025
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000299791 520__ $$aThe transcription factor interferon regulatory factor 4 (IRF4) is crucial for the fate determination of pro-inflammatory T helper (Th) 17 and the functionally opposing group of immunomodulatory regulatory T (Treg) cells. However, the molecular mechanisms of how IRF4 steers diverse transcriptional programs in Th17 and Treg cells are far from being definitive. Here, we integrated data derived from affinity-purification and full mass-spectrometry-based proteome analysis with chromatin immunoprecipitation sequencing. This allowed the characterization of subtype-specific molecular programs and the identification of IRF4 interactors in the Th17/Treg context. Our data reveal that IRF4-interacting transcription factors are recruited to IRF composite elements for the regulation of cell-type-specific transcriptional programs as exemplarily demonstrated for FLI1, which, in cooperation with IRF4, promotes Th17-specific gene expression. FLI1 inhibition markedly impaired Th17 differentiation. The present 'omics' dataset provides a valuable resource for studying IRF4-mediated gene regulatory programs in pro- and anti-inflammatory immune responses.
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000299791 650_7 $$2Other$$aCP: Immunology
000299791 650_7 $$2Other$$aChIP-seq
000299791 650_7 $$2Other$$aFLI1
000299791 650_7 $$2Other$$aIRF4
000299791 650_7 $$2Other$$aTh17 cells
000299791 650_7 $$2Other$$aTreg cells
000299791 650_7 $$2Other$$acomposite motif
000299791 650_7 $$2Other$$aprotein-protein interaction
000299791 650_7 $$2Other$$aproteomics
000299791 7001_ $$aSprang, Maximilian$$b1
000299791 7001_ $$aCihan, Mert$$b2
000299791 7001_ $$aWelzel, Mareen$$b3
000299791 7001_ $$aNurbekova, Assel$$b4
000299791 7001_ $$aRomaniuk, Karolina$$b5
000299791 7001_ $$aDietzen, Sarah$$b6
000299791 7001_ $$aKlein, Matthias$$b7
000299791 7001_ $$aBündgen, Georg$$b8
000299791 7001_ $$aEmelianov, Maxim$$b9
000299791 7001_ $$aHarms, Gregory$$b10
000299791 7001_ $$aRajalingam, Krishnaraj$$b11
000299791 7001_ $$aZiesmann, Tanja$$b12
000299791 7001_ $$aPape, Katrin$$b13
000299791 7001_ $$aWasser, Beatrice$$b14
000299791 7001_ $$0P:(DE-He78)4569ef2919d2438765ad71515f53646b$$aGomez-Zepeda, David$$b15$$udkfz
000299791 7001_ $$aBraband, Kathrin$$b16
000299791 7001_ $$aDelacher, Michael$$b17
000299791 7001_ $$aLemmermann, Niels$$b18
000299791 7001_ $$aBittner, Stefan$$b19
000299791 7001_ $$aAndrade-Navarro, Miguel A$$b20
000299791 7001_ $$0P:(DE-He78)74e391c68d7926be83d679f3d8891e33$$aTenzer, Stefan$$b21$$udkfz
000299791 7001_ $$aLuck, Katja$$b22
000299791 7001_ $$aBopp, Tobias$$b23
000299791 7001_ $$aDistler, Ute$$b24
000299791 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2025.115407$$gVol. 44, no. 3, p. 115407 -$$n3$$p115407$$tCell reports$$v44$$x2211-1247$$y2025
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