TY  - JOUR
AU  - Abe, Shinya
AU  - Kagao, Moe
AU  - Asahi, Takuma
AU  - Kato, Ryoma
AU  - Tani-Ichi, Shizue
AU  - Shimba, Akihiro
AU  - Ishibashi, Riki
AU  - Miyachi, Hitoshi
AU  - Kitano, Satsuki
AU  - Miyazaki, Masaki
AU  - Rodewald, Hans-Reimer
AU  - Toyoshima, Fumiko
AU  - Ikuta, Koichi
TI  - The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow.
JO  - The journal of immunology
VL  - 214
IS  - 4
SN  - 0022-1767
CY  - Rockville, Md.
PB  - American Association of Immunologists
M1  - DKFZ-2025-00552
SP  - 575-581
PY  - 2025
N1  - 2025 Apr 1;214(4):575-581
AB  - Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To investigate the role of RORα in ILC1s, we analyzed bone marrow (BM) chimeras of RORα-deficient mice. ILC1s derived from RORα-deficient BM cells were significantly reduced in various tissues, including the intestine, indicating a hematopoietic cell-intrinsic need for RORα in ILC1 development. Developmental stage-specific RORα-deficient mice showed a decrease in adult liver and BM IL-7R+ ILC1s and an increase in BM NK cells, whereas fetal liver ILC1s and adult liver IL-7R- ILC1s remained unchanged. Furthermore, RORα is primarily required for IL-7R+ precursor stages and partially affects small intestine ILC1 after differentiation. This study suggests that RORα promotes ILC1 differentiation while suppressing NK cell differentiation at the ILC precursor stage in the adult BM.
KW  - RORα (Other)
KW  - group 1 ILC (Other)
KW  - innate lymphoid precursor (Other)
KW  - type 1 innate lymphoid cell (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40079843
DO  - DOI:10.1093/jimmun/vkaf001
UR  - https://inrepo02.dkfz.de/record/299797
ER  -