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@ARTICLE{Abe:299797,
      author       = {S. Abe and M. Kagao and T. Asahi and R. Kato and S.
                      Tani-Ichi and A. Shimba and R. Ishibashi and H. Miyachi and
                      S. Kitano and M. Miyazaki and H.-R. Rodewald$^*$ and F.
                      Toyoshima and K. Ikuta},
      title        = {{T}he transcription factor {ROR}α is required for the
                      development of type 1 innate lymphoid cells in adult bone
                      marrow.},
      journal      = {The journal of immunology},
      volume       = {214},
      number       = {4},
      issn         = {0022-1767},
      address      = {Rockville, Md.},
      publisher    = {American Association of Immunologists},
      reportid     = {DKFZ-2025-00552},
      pages        = {575-581},
      year         = {2025},
      note         = {2025 Apr 1;214(4):575-581},
      abstract     = {Type 1 innate lymphoid cells (ILC1s) respond to infections
                      and tumors by producing IFN-γ. Although RAR-related orphan
                      receptor α (RORα) is required for ILC2s and some ILC3s,
                      its role in ILC1 development remains controversial. To
                      investigate the role of RORα in ILC1s, we analyzed bone
                      marrow (BM) chimeras of RORα-deficient mice. ILC1s derived
                      from RORα-deficient BM cells were significantly reduced in
                      various tissues, including the intestine, indicating a
                      hematopoietic cell-intrinsic need for RORα in ILC1
                      development. Developmental stage-specific RORα-deficient
                      mice showed a decrease in adult liver and BM IL-7R+ ILC1s
                      and an increase in BM NK cells, whereas fetal liver ILC1s
                      and adult liver IL-7R- ILC1s remained unchanged.
                      Furthermore, RORα is primarily required for IL-7R+
                      precursor stages and partially affects small intestine ILC1
                      after differentiation. This study suggests that RORα
                      promotes ILC1 differentiation while suppressing NK cell
                      differentiation at the ILC precursor stage in the adult BM.},
      keywords     = {RORα (Other) / group 1 ILC (Other) / innate lymphoid
                      precursor (Other) / type 1 innate lymphoid cell (Other)},
      cin          = {D110},
      ddc          = {610},
      cid          = {I:(DE-He78)D110-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40079843},
      doi          = {10.1093/jimmun/vkaf001},
      url          = {https://inrepo02.dkfz.de/record/299797},
}