000299822 001__ 299822 000299822 005__ 20250323015709.0 000299822 0247_ $$2doi$$a10.1016/j.esmoop.2025.104301 000299822 0247_ $$2pmid$$apmid:40086399 000299822 0247_ $$2altmetric$$aaltmetric:175168342 000299822 037__ $$aDKFZ-2025-00559 000299822 041__ $$aEnglish 000299822 082__ $$a610 000299822 1001_ $$aMarkozannes, G.$$b0 000299822 245__ $$aThe role of physical activity, sedentary behaviour, diet, adiposity and body composition on health-related quality of life and cancer-related fatigue after diagnosis of colorectal cancer: a Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis. 000299822 260__ $$a[London]$$bElsevier$$c2025 000299822 3367_ $$2DRIVER$$aarticle 000299822 3367_ $$2DataCite$$aOutput Types/Journal article 000299822 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1742292108_12554$$xReview Article 000299822 3367_ $$2BibTeX$$aARTICLE 000299822 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000299822 3367_ $$00$$2EndNote$$aJournal Article 000299822 520__ $$aThe impact of physical activity, sedentary behaviour, diet, adiposity, and body composition on health-related quality of life (HRQoL) and cancer-related fatigue among colorectal cancer survivors remains uncertain.PubMed, Embase, and CENTRAL were systematically searched until April 2023 for relevant randomised controlled trials (RCTs) and cohort studies. Random-effects meta-analyses or descriptive syntheses were conducted depending on the number of studies. The evidence was interpreted and graded by an independent World Cancer Research Fund Expert Committee and Expert Panel.We included 31 RCTs (18 exercise, 14 diet) and 30 cohort studies (8 physical activity, 3 sedentary behaviour, 13 diet, 9 adiposity and body composition). Meta-analyses were possible for exercise RCTs that showed non-significant effects but indicative of improved HRQoL (overall four trials for global HRQoL, physical and emotional well-being) and fatigue (five trials). These studies were rated at a high risk of bias (RoB), and evidence was graded as 'very low certainty of an effect'. Descriptive synthesis of interventions to improve diet quality suggested small improvements in global HRQoL and physical well-being, but with a high RoB rating leading to a 'low certainty' grading. Evidence from RCTs on probiotics and supplements and evidence from observational studies on sedentary behaviour, and various dietary and body composition factors was generally inconsistent and too scarce to draw conclusions.Exercise and diet quality interventions might improve HRQoL and fatigue outcomes in colorectal cancer survivors. The evidence overall was limited and should be strengthened by larger, well-designed RCTs across the cancer continuum. 000299822 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0 000299822 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de 000299822 650_7 $$2Other$$aadiposity 000299822 650_7 $$2Other$$acolorectal cancer survivors 000299822 650_7 $$2Other$$adiet 000299822 650_7 $$2Other$$afatigue 000299822 650_7 $$2Other$$aphysical activity 000299822 650_7 $$2Other$$aquality of life 000299822 7001_ $$aCividini, S.$$b1 000299822 7001_ $$aAune, D.$$b2 000299822 7001_ $$aBecerra-Tomás, N.$$b3 000299822 7001_ $$aKiss, S.$$b4 000299822 7001_ $$aBalducci, K.$$b5 000299822 7001_ $$aVieira, R.$$b6 000299822 7001_ $$aCariolou, M.$$b7 000299822 7001_ $$aJayedi, A.$$b8 000299822 7001_ $$aGreenwood, D. C.$$b9 000299822 7001_ $$aBrockton, N. T.$$b10 000299822 7001_ $$aCroker, H.$$b11 000299822 7001_ $$aMitrou, P.$$b12 000299822 7001_ $$aCopson, E.$$b13 000299822 7001_ $$aRenehan, A. G.$$b14 000299822 7001_ $$aBours, M.$$b15 000299822 7001_ $$aDemark-Wahnefried, W.$$b16 000299822 7001_ $$aHudson, M. M.$$b17 000299822 7001_ $$aMay, A. M.$$b18 000299822 7001_ $$aOdedina, F. T.$$b19 000299822 7001_ $$aSkinner, R.$$b20 000299822 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, K.$$b21$$udkfz 000299822 7001_ $$aTjønneland, A.$$b22 000299822 7001_ $$aVelikova, G.$$b23 000299822 7001_ $$aBaskin, M. L.$$b24 000299822 7001_ $$aChowdhury, R.$$b25 000299822 7001_ $$aHill, L.$$b26 000299822 7001_ $$aLewis, S. J.$$b27 000299822 7001_ $$aSeidell, J.$$b28 000299822 7001_ $$aWeijenberg, M. P.$$b29 000299822 7001_ $$aKrebs, J.$$b30 000299822 7001_ $$aCross, A. J.$$b31 000299822 7001_ $$aTsilidis, K. K.$$b32 000299822 7001_ $$aChan, D. S. 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