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@ARTICLE{Markozannes:299822,
      author       = {G. Markozannes and S. Cividini and D. Aune and N.
                      Becerra-Tomás and S. Kiss and K. Balducci and R. Vieira and
                      M. Cariolou and A. Jayedi and D. C. Greenwood and N. T.
                      Brockton and H. Croker and P. Mitrou and E. Copson and A. G.
                      Renehan and M. Bours and W. Demark-Wahnefried and M. M.
                      Hudson and A. M. May and F. T. Odedina and R. Skinner and K.
                      Steindorf$^*$ and A. Tjønneland and G. Velikova and M. L.
                      Baskin and R. Chowdhury and L. Hill and S. J. Lewis and J.
                      Seidell and M. P. Weijenberg and J. Krebs and A. J. Cross
                      and K. K. Tsilidis and D. S. M. Chan},
      title        = {{T}he role of physical activity, sedentary behaviour, diet,
                      adiposity and body composition on health-related quality of
                      life and cancer-related fatigue after diagnosis of
                      colorectal cancer: a {G}lobal {C}ancer {U}pdate {P}rogramme
                      ({CUP} {G}lobal) systematic literature review and
                      meta-analysis.},
      journal      = {ESMO open},
      volume       = {10},
      number       = {4},
      issn         = {2059-7029},
      address      = {[London]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00559},
      pages        = {104301},
      year         = {2025},
      abstract     = {The impact of physical activity, sedentary behaviour, diet,
                      adiposity, and body composition on health-related quality of
                      life (HRQoL) and cancer-related fatigue among colorectal
                      cancer survivors remains uncertain.PubMed, Embase, and
                      CENTRAL were systematically searched until April 2023 for
                      relevant randomised controlled trials (RCTs) and cohort
                      studies. Random-effects meta-analyses or descriptive
                      syntheses were conducted depending on the number of studies.
                      The evidence was interpreted and graded by an independent
                      World Cancer Research Fund Expert Committee and Expert
                      Panel.We included 31 RCTs (18 exercise, 14 diet) and 30
                      cohort studies (8 physical activity, 3 sedentary behaviour,
                      13 diet, 9 adiposity and body composition). Meta-analyses
                      were possible for exercise RCTs that showed non-significant
                      effects but indicative of improved HRQoL (overall four
                      trials for global HRQoL, physical and emotional well-being)
                      and fatigue (five trials). These studies were rated at a
                      high risk of bias (RoB), and evidence was graded as 'very
                      low certainty of an effect'. Descriptive synthesis of
                      interventions to improve diet quality suggested small
                      improvements in global HRQoL and physical well-being, but
                      with a high RoB rating leading to a 'low certainty' grading.
                      Evidence from RCTs on probiotics and supplements and
                      evidence from observational studies on sedentary behaviour,
                      and various dietary and body composition factors was
                      generally inconsistent and too scarce to draw
                      conclusions.Exercise and diet quality interventions might
                      improve HRQoL and fatigue outcomes in colorectal cancer
                      survivors. The evidence overall was limited and should be
                      strengthened by larger, well-designed RCTs across the cancer
                      continuum.},
      subtyp        = {Review Article},
      keywords     = {adiposity (Other) / colorectal cancer survivors (Other) /
                      diet (Other) / fatigue (Other) / physical activity (Other) /
                      quality of life (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40086399},
      doi          = {10.1016/j.esmoop.2025.104301},
      url          = {https://inrepo02.dkfz.de/record/299822},
}