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@ARTICLE{Lu:299829,
      author       = {Z. Lu and O. Stencel and W. Liu and E. Vasileiou and H. C.
                      Xu and P. Pandey and P. Stachura and A. Elwy and A. Tsombal
                      and A.-S. Mai and F. Auer and M. N. F. Morcos and M. Seidl
                      and S. Koziel and P.-M. Bruch and S. Dietrich and S. Elitzur
                      and G. Hartmann and K. S. Lang and S. Janssen and U. Fischer
                      and S. Bhatia and P. A. Lang and A. Borkhardt and J.
                      Hauer$^*$ and A. A. Pandyra},
      title        = {{I}mmune training enhances anti-viral responses and
                      improves outcomes in {P}ax5-/+ mice susceptible to chronic
                      infection.},
      journal      = {EMBO molecular medicine},
      volume       = {17},
      number       = {4},
      issn         = {1757-4676},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2025-00566},
      pages        = {696-721},
      year         = {2025},
      note         = {2025 Apr;17(4):696-721},
      abstract     = {Viral infections pose a significant global burden. Host
                      susceptibility to pathogens is determined by many factors
                      including genetic variation that can lead to immunodeficient
                      or dysregulated antiviral immune responses. Pax5
                      heterozygosity (Pax5-/+), resulting in reduced PAX5 levels
                      in mice, mimics germline or somatic PAX5 dysregulation
                      contributing to diseases such as childhood B-cell precursor
                      acute lymphoblastic leukemia (B-ALL). In contrast to the
                      well-characterized roles of PAX5 during early B-cell
                      development, little is known about how Pax5 heterozygosity
                      impacts antiviral responses. We infected Pax5-/+ mice with
                      the noncytopathic Lymphocytic Choriomeningitis Virus (LCMV)
                      and found that infection with the chronic Docile strain
                      resulted in decreased survival of Pax5-/+ mice. While early
                      adaptive CD8+ T-cell (CTL) immunity was robust in Pax5-/+
                      mice, LCMV-specific neutralizing antibody production was
                      compromised leading to impaired long-term viral clearance
                      and a pro-inflammatory milieu in the bone marrow (BM). Here
                      we show that survival outcomes were improved upon
                      prophylactic treatment with the β-glucan immune trainer
                      through induction of heterologous protection against chronic
                      infection. β-Glucan enhanced viral clearance, CTL immunity,
                      neutralizing antibody production and reduced monocyte
                      immunosuppression in multiple LCMV-resident host organs. New
                      insight from this study will help design effective
                      prophylactic treatment strategies against chronic viral
                      infections, particularly in genetically predisposed
                      susceptible hosts.},
      keywords     = {Chronic Infection (Other) / LCMV (Other) / PAX5 (Other) /
                      Trained Immunity (Other) / β-glucan (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40082582},
      doi          = {10.1038/s44321-025-00208-4},
      url          = {https://inrepo02.dkfz.de/record/299829},
}