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@ARTICLE{Ruck:299842,
author = {L. Ruck and N. Egger and T. Wilferth and J. Schirmer and L.
V. Gast and S. Nagelstraßer and S. Wildenberg and A. Bitz
and T. Lanz and T. Platt$^*$ and S. Konstandin and C. Kopp
and M. Uder and A. Nagel$^*$},
title = {{I}nterleaved 23{N}a/1{H} {MRI} of the human heart at 7 {T}
using a combined 23{N}a/1{H} coil setup and 1{H} parallel
transmission.},
journal = {Magnetic resonance in medicine},
volume = {94},
number = {1},
issn = {1522-2594},
address = {New York, NY [u.a.]},
publisher = {Wiley-Liss},
reportid = {DKFZ-2025-00579},
pages = {231-241},
year = {2025},
note = {#LA:E020# / Volume 94, Issue 1, July 2025, Pages 231-241},
abstract = {To evaluate the feasibility of interleaved 23Na/1H cardiac
MRI at 7 T using 1H parallel transmission (pTx) pulses.A
combined setup consisting of a 23Na volume coil and two 1H
transceiver arrays was employed and the transmit and receive
characteristics were compared in vitro with those of the
uncombined radiofrequency coils. Furthermore, the
implemented interleaved 23Na/1H pTx sequence was validated
in phantom measurements and applied to four healthy
subjects. For the latter, three customized 1H excitation
pulses (universal and individual phase shims (UPS/IPS) and
individual 4kT pulses (4kT)) were employed in the
interleaved 23Na/1H pTx sequence and compared with the
vendor-provided default cardiac phase shim (DPS).Combining
both coils resulted in a reduction of the mean 23Na transmit
field (B1 +) efficiency and 23Na signal-to-noise ratio by
$18.9\%$ and $15.4\%$ for the combined setup, whereas the 1H
B1 + efficiency was less influenced $(-4.7\%).$ Compared
with single-nuclear acquisitions, interleaved dual-nuclear
23Na/1H MRI showed negligible influence on 23Na and 1H image
quality. For all three customized 1H pTx pulses the B1 +
homogeneity was improved (coefficients of variation: CVUPS =
0.30, CVIPS = 0.23, CV4kT = 0.15) and no 1H signal dropouts
occurred compared with the vendor-provided default phase
shim (CVDPS = 0.37).The incorporation of customized 1H pTx
pulses in an interleaved 23Na/1H sequence scheme was
successfully demonstrated at 7 T and improvements of the 1H
B1 + homogeneity within the heart were shown. Combining
interleaved 23Na/1H MRI with 1H pTx is an important tool to
enable robust quantification of myocardial tissue sodium
concentrations at 7 T within clinically acceptable
acquisition times.},
keywords = {23Na RF birdcage coil (Other) / 7 Tesla (Other) / cardiac
sodium (23Na) MRI (Other) / interleaved acquisition (Other)
/ parallel transmission (pTx) (Other)},
cin = {E020},
ddc = {610},
cid = {I:(DE-He78)E020-20160331},
pnm = {315 - Bildgebung und Radioonkologie (POF4-315)},
pid = {G:(DE-HGF)POF4-315},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40065602},
doi = {10.1002/mrm.30426},
url = {https://inrepo02.dkfz.de/record/299842},
}