TY  - JOUR
AU  - Berclaz, Luc M
AU  - Di Gioia, Dorit
AU  - Jurinovic, Vindi
AU  - Völkl, Michael
AU  - Güler, Sinan E
AU  - Albertsmeier, Markus
AU  - Klein, Alexander
AU  - Dürr, Hans Roland
AU  - Mansoorian, Sina
AU  - Knösel, Thomas
AU  - Kunz, Wolfgang G
AU  - von Bergwelt-Baildon, Michael
AU  - Lindner, Lars H
AU  - Burkhard-Meier, Anton
TI  - LDH and hemoglobin outperform systemic inflammatory indices as prognostic factors in patients with soft tissue sarcoma undergoing neoadjuvant treatment.
JO  - BMC cancer
VL  - 25
IS  - 1
SN  - 1471-2407
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00584
SP  - 496
PY  - 2025
AB  - The current understanding of the prognostic value of routine pre-treatment laboratory parameters in patients with high-risk soft tissue sarcoma (HR-STS) is limited. We sought to analyze several inflammatory biomarkers in a large cohort of HR-STS patients undergoing neoadjuvant therapy followed by curative surgical resection.123 patients with locally advanced high-risk undifferentiated pleomorphic sarcoma (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), and synovial sarcoma (SS) who underwent preoperative chemotherapy and regional hyperthermia (RHT) between 2014 and 2022 were retrospectively evaluated. The association of several pre-treatment laboratory parameters with radiologic treatment response, event-free survival (EFS), and overall survival (OS), were analyzed.Low pre-treatment hemoglobin (HR 2.51, p = 0.018; HR 2.78, p = 0.030) and lactate dehydrogenase (LDH, HR 0.29, p = 0.0044; HR 0.23, p = 0.010) were significantly associated with EFS and OS in the multivariable analysis. Systemic inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR) did not have a significant impact on survival. Low C-reactive protein (CRP) and high albumin values were associated with poor radiologic response according to RECIST (p = 0.021 and p = 0.010, respectively).Pre-treatment LDH and hemoglobin are strong independent predictors of survival in HR-STS patients. Systemic inflammatory indices based on circulating immune cells may not serve as reliable prognostic factors for HR-STS patients undergoing curative-intent treatment. Higher pre-treatment albumin levels and lower CRP values may reflect a reduced inflammatory status and could be associated with a poorer radiologic response to preoperative treatment.
KW  - Humans
KW  - Female
KW  - Male
KW  - Middle Aged
KW  - Sarcoma: therapy
KW  - Sarcoma: blood
KW  - Sarcoma: drug therapy
KW  - Sarcoma: mortality
KW  - Neoadjuvant Therapy: methods
KW  - Prognosis
KW  - Hemoglobins: analysis
KW  - Hemoglobins: metabolism
KW  - Adult
KW  - Aged
KW  - Retrospective Studies
KW  - L-Lactate Dehydrogenase: blood
KW  - Inflammation: blood
KW  - Biomarkers, Tumor: blood
KW  - C-Reactive Protein: metabolism
KW  - C-Reactive Protein: analysis
KW  - Young Adult
KW  - Aged, 80 and over
KW  - Hyperthermia, Induced: methods
KW  - Chemotherapy (Other)
KW  - Hemoglobin (Other)
KW  - LDH (Other)
KW  - Regional hyperthermia (Other)
KW  - Soft tissue sarcoma (Other)
KW  - Systemic inflammatory index (Other)
KW  - Hemoglobins (NLM Chemicals)
KW  - L-Lactate Dehydrogenase (NLM Chemicals)
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - C-Reactive Protein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40102864
DO  - DOI:10.1186/s12885-025-13889-4
UR  - https://inrepo02.dkfz.de/record/299848
ER  -