% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Berclaz:299848,
      author       = {L. M. Berclaz$^*$ and D. Di Gioia and V. Jurinovic and M.
                      Völkl and S. E. Güler and M. Albertsmeier and A. Klein and
                      H. R. Dürr and S. Mansoorian and T. Knösel and W. G. Kunz
                      and M. von Bergwelt-Baildon$^*$ and L. H. Lindner and A.
                      Burkhard-Meier},
      title        = {{LDH} and hemoglobin outperform systemic inflammatory
                      indices as prognostic factors in patients with soft tissue
                      sarcoma undergoing neoadjuvant treatment.},
      journal      = {BMC cancer},
      volume       = {25},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-00584},
      pages        = {496},
      year         = {2025},
      abstract     = {The current understanding of the prognostic value of
                      routine pre-treatment laboratory parameters in patients with
                      high-risk soft tissue sarcoma (HR-STS) is limited. We sought
                      to analyze several inflammatory biomarkers in a large cohort
                      of HR-STS patients undergoing neoadjuvant therapy followed
                      by curative surgical resection.123 patients with locally
                      advanced high-risk undifferentiated pleomorphic sarcoma
                      (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), and synovial
                      sarcoma (SS) who underwent preoperative chemotherapy and
                      regional hyperthermia (RHT) between 2014 and 2022 were
                      retrospectively evaluated. The association of several
                      pre-treatment laboratory parameters with radiologic
                      treatment response, event-free survival (EFS), and overall
                      survival (OS), were analyzed.Low pre-treatment hemoglobin
                      (HR 2.51, p = 0.018; HR 2.78, p = 0.030) and lactate
                      dehydrogenase (LDH, HR 0.29, p = 0.0044; HR 0.23, p = 0.010)
                      were significantly associated with EFS and OS in the
                      multivariable analysis. Systemic inflammatory indices such
                      as the neutrophil-to-lymphocyte ratio (NLR) did not have a
                      significant impact on survival. Low C-reactive protein (CRP)
                      and high albumin values were associated with poor radiologic
                      response according to RECIST (p = 0.021 and p = 0.010,
                      respectively).Pre-treatment LDH and hemoglobin are strong
                      independent predictors of survival in HR-STS patients.
                      Systemic inflammatory indices based on circulating immune
                      cells may not serve as reliable prognostic factors for
                      HR-STS patients undergoing curative-intent treatment. Higher
                      pre-treatment albumin levels and lower CRP values may
                      reflect a reduced inflammatory status and could be
                      associated with a poorer radiologic response to preoperative
                      treatment.},
      keywords     = {Humans / Female / Male / Middle Aged / Sarcoma: therapy /
                      Sarcoma: blood / Sarcoma: drug therapy / Sarcoma: mortality
                      / Neoadjuvant Therapy: methods / Prognosis / Hemoglobins:
                      analysis / Hemoglobins: metabolism / Adult / Aged /
                      Retrospective Studies / L-Lactate Dehydrogenase: blood /
                      Inflammation: blood / Biomarkers, Tumor: blood / C-Reactive
                      Protein: metabolism / C-Reactive Protein: analysis / Young
                      Adult / Aged, 80 and over / Hyperthermia, Induced: methods /
                      Chemotherapy (Other) / Hemoglobin (Other) / LDH (Other) /
                      Regional hyperthermia (Other) / Soft tissue sarcoma (Other)
                      / Systemic inflammatory index (Other) / Hemoglobins (NLM
                      Chemicals) / L-Lactate Dehydrogenase (NLM Chemicals) /
                      Biomarkers, Tumor (NLM Chemicals) / C-Reactive Protein (NLM
                      Chemicals)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40102864},
      doi          = {10.1186/s12885-025-13889-4},
      url          = {https://inrepo02.dkfz.de/record/299848},
}