%0 Journal Article
%A Möhrmann, Lino
%A Rostock, Lysann
%A Werner, Maximilian
%A Oleś, Małgorzata
%A Arnold, Jonas
%A Paramasivam, Nagarajan
%A Jöhrens, Korinna
%A Rupp, Luise
%A Schmitz, Marc
%A Richter, Daniela
%A Uhrig, Sebastian
%A Fröhlich, Martina Antonia
%A Hutter, Barbara
%A Hüllein, Jennifer
%A Jahn, Arne
%A Arlt, Marie
%A Möhrmann, Elena E
%A Hanf, Dorothea
%A Gieldon, Laura
%A Kreutzfeldt, Simon
%A Heilig, Christoph E
%A Teleanu, Maria-Veronica
%A Lipka, Daniel B
%A Beck, Katja
%A Baude-Müller, Annika
%A Mock, Andreas
%A Jelas, Ivan
%A Rieke, Damian T
%A Wiesweg, Marcel
%A Brandts, Christian
%A Boerries, Melanie
%A Illert, Anna L
%A Desuki, Alexander
%A Kindler, Thomas
%A Krackhardt, Angela M
%A Westphalen, C Benedikt
%A Christopoulos, Petros
%A Apostolidis, Leonidas
%A Stenzinger, Albrecht
%A Allgäuer, Michael
%A Neumann, Olaf
%A Kerle, Irina
%A Horak, Peter
%A Heining, Christoph
%A Grosch, Heidrun
%A Schröck, Evelin
%A Hübschmann, Daniel
%A Fröhling, Stefan
%A Glimm, Hanno
%T Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors.
%J Med
%V 6
%N 6
%@ 2666-6340
%C Amsterdam
%I Elsevier
%M DKFZ-2025-00591
%P 100612
%D 2025
%Z #LA:B340#LA:B280#LA:W015 / 2025 Jun 13;6(6):100612/ Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), translational Functional Cancer Genomics, DKFZ Heidelberg, Heidelberg, Germany,  Innovation and Service Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany
%X Thymic epithelial tumors (TETs) are rare malignancies with limited treatment options and underexplored molecular features.We examined the genomic landscape and therapeutic outcomes in 81 patients with advanced TETs, including thymic carcinomas (TCs), thymomas, and thymic neuroendocrine neoplasms (TNENs), who were enrolled in the MASTER trial, a prospective observational precision oncology trial.Using whole-genome-sequencing and whole-exome-sequencing analysis, transcriptome analysis, and methylome analysis, we identified distinct molecular features across TET subtypes, including a higher tumor mutational burden in TC and pathogenic germline variants in 18
%K Translation to patients (Other)
%K molecular profiling (Other)
%K multiomics (Other)
%K precision oncology (Other)
%K prospective observational study (Other)
%K targeted therapy (Other)
%K thymic carcinoma (Other)
%K thymic epithelial tumor (Other)
%K thymic neuroendocrine neoplasm (Other)
%K thymoma (Other)
%K whole-genome sequencing (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40107270
%R 10.1016/j.medj.2025.100612
%U https://inrepo02.dkfz.de/record/299861