%0 Journal Article
%A Hemminki, Kari
%A Zitricky, Frantisek
%A Sundquist, Kristina
%A Sundquist, Jan
%A Försti, Asta
%A Hemminki, Akseli
%T Lung cancer risk between maternal and paternal half-siblings points to main environmental causation and targets for prevention.
%J Lung cancer
%V 202
%@ 0169-5002
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2025-00595
%P 108500
%D 2025
%X Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only maternal half-siblings share the childhood environment to the same extent than full siblings.We used Swedish nation-wide data on family structures and cancers up to year 2021 to determined LC risk (standardized incidence ratio, SIR with 95
%K Adenocarcinoma (Other)
%K Childhood environment (Other)
%K Familial cancer (Other)
%K Maternal half-sibling (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40117846
%R 10.1016/j.lungcan.2025.108500
%U https://inrepo02.dkfz.de/record/300095