TY  - JOUR
AU  - Certa, Franziska
AU  - Horn, Peter A
AU  - Keyl, Julius
AU  - Mende, Bastian
AU  - Lueong, Smiths
AU  - Hilser, Thomas
AU  - Theurer, Sarah
AU  - Virchow, Isabel
AU  - Zaun, Yasmin
AU  - Pogorzelski, Michael
AU  - Metzenmacher, Martin
AU  - Kalkavan, Halime
AU  - Kasper, Stefan
AU  - Schuler, Martin
AU  - Wiesweg, Marcel
AU  - Zaun, Gregor
TI  - ABO-Blood Group Associates With Survival Outcomes in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Pembrolizumab Monotherapy.
JO  - Thoracic cancer
VL  - 16
IS  - 6
SN  - 1759-7706
CY  - Hoboken, NJ ˜[u.a.]œ
PB  - Wiley-Blackwell
M1  - DKFZ-2025-00596
SP  - e70037
PY  - 2025
AB  - In patients with metastatic non-small cell lung cancer (NSCLC) with high programmed death-ligand 1 (PD-L1) expression, there is still a lack of biomarkers to identify patients with maximum benefit from first-line treatment with checkpoint inhibitor therapy (CIT) alone. This work examines the impact of different ABO blood groups (BG) on the response to CIT monotherapy.Retrospective analysis of patients with stage IV NSCLC and high PD-L1 expression (tumor proportional score/TPS ≥ 50
KW  - Humans
KW  - Antibodies, Monoclonal, Humanized: therapeutic use
KW  - Carcinoma, Non-Small-Cell Lung: drug therapy
KW  - Carcinoma, Non-Small-Cell Lung: mortality
KW  - Carcinoma, Non-Small-Cell Lung: pathology
KW  - Lung Neoplasms: drug therapy
KW  - Lung Neoplasms: mortality
KW  - Lung Neoplasms: pathology
KW  - Male
KW  - Female
KW  - ABO Blood-Group System
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Aged
KW  - Adult
KW  - Aged, 80 and over
KW  - Prognosis
KW  - Antineoplastic Agents, Immunological: therapeutic use
KW  - Survival Rate
KW  - blood group (Other)
KW  - checkpoint inhibitor (Other)
KW  - non‐small cell lung cancer (Other)
KW  - predictive biomarkers (Other)
KW  - pembrolizumab (NLM Chemicals)
KW  - Antibodies, Monoclonal, Humanized (NLM Chemicals)
KW  - ABO Blood-Group System (NLM Chemicals)
KW  - Antineoplastic Agents, Immunological (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40114329
C2  - pmc:PMC11925720
DO  - DOI:10.1111/1759-7714.70037
UR  - https://inrepo02.dkfz.de/record/300096
ER  -