%0 Journal Article
%A Mandic, Marko
%A Safizadeh, Fatemeh
%A Schöttker, Ben
%A Holleczek, Bernd
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Body mass index across adulthood, weight gain and cancer risk: a population-based cohort study.
%J BMC cancer
%V 25
%N 1
%@ 1471-2407
%C London
%I BioMed Central
%M DKFZ-2025-00626
%P 488
%D 2025
%Z #EA:C070#LA:C070#
%X Although the association between excess weight and cancer risk is well established, it is not known how this association evolves across the lifespan. We aimed to investigate the strength of the association of excess weight at different ages in adulthood and adult weight gain with cancer risk.We used data from a German population-based cohort study of 9,218 participants aged 50-75 (mean 62) years recruited between 2000 and 2002. Participants provided socio-demographic, medical, and lifestyle data, including self-reported current height and weight (at ages 20, 30, 40, 50 and baseline). Main exposures were body mass index (BMI, kg/m2) at different ages and weight change (kg) since age 20. The outcome was obesity-related cancer (13 types). Hazard ratios (HRs) and 95
%K Humans
%K Body Mass Index
%K Middle Aged
%K Male
%K Weight Gain
%K Female
%K Neoplasms: epidemiology
%K Neoplasms: etiology
%K Aged
%K Obesity: complications
%K Obesity: epidemiology
%K Risk Factors
%K Germany: epidemiology
%K Cohort Studies
%K Proportional Hazards Models
%K Adult
%K Overweight: complications
%K Overweight: epidemiology
%K Follow-Up Studies
%K Breast cancer (Other)
%K Cancer (Other)
%K Colorectal cancer (Other)
%K Excess weight (Other)
%K Obesity (Other)
%K Overweight (Other)
%K Weight gain (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40097970
%2 pmc:PMC11912780
%R 10.1186/s12885-025-13855-0
%U https://inrepo02.dkfz.de/record/300129