TY  - JOUR
AU  - Mandic, Marko
AU  - Safizadeh, Fatemeh
AU  - Schöttker, Ben
AU  - Holleczek, Bernd
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Body mass index across adulthood, weight gain and cancer risk: a population-based cohort study.
JO  - BMC cancer
VL  - 25
IS  - 1
SN  - 1471-2407
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00626
SP  - 488
PY  - 2025
N1  - #EA:C070#LA:C070#
AB  - Although the association between excess weight and cancer risk is well established, it is not known how this association evolves across the lifespan. We aimed to investigate the strength of the association of excess weight at different ages in adulthood and adult weight gain with cancer risk.We used data from a German population-based cohort study of 9,218 participants aged 50-75 (mean 62) years recruited between 2000 and 2002. Participants provided socio-demographic, medical, and lifestyle data, including self-reported current height and weight (at ages 20, 30, 40, 50 and baseline). Main exposures were body mass index (BMI, kg/m2) at different ages and weight change (kg) since age 20. The outcome was obesity-related cancer (13 types). Hazard ratios (HRs) and 95
KW  - Humans
KW  - Body Mass Index
KW  - Middle Aged
KW  - Male
KW  - Weight Gain
KW  - Female
KW  - Neoplasms: epidemiology
KW  - Neoplasms: etiology
KW  - Aged
KW  - Obesity: complications
KW  - Obesity: epidemiology
KW  - Risk Factors
KW  - Germany: epidemiology
KW  - Cohort Studies
KW  - Proportional Hazards Models
KW  - Adult
KW  - Overweight: complications
KW  - Overweight: epidemiology
KW  - Follow-Up Studies
KW  - Breast cancer (Other)
KW  - Cancer (Other)
KW  - Colorectal cancer (Other)
KW  - Excess weight (Other)
KW  - Obesity (Other)
KW  - Overweight (Other)
KW  - Weight gain (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40097970
C2  - pmc:PMC11912780
DO  - DOI:10.1186/s12885-025-13855-0
UR  - https://inrepo02.dkfz.de/record/300129
ER  -