%0 Journal Article
%A Aglago, Elom K
%A Ramos, Ines
%A Keski-Rahkonen, Pekka
%A Chatziioannou, Chrysovalantou
%A Freisling, Heinz
%A Fedirko, Veronika
%A Gunter, Marc J
%A Dahm, Christina C
%A Langmann, Fie
%A Bondonno, Nicola
%A Tjønneland, Anne
%A Severi, Gianluca
%A Truong, Therese
%A Katzke, Verena
%A Kaaks, Rudolf
%A Bergmann, Manuela
%A Schulze, Matthias B
%A Masala, Giovanna
%A Pala, Valeria
%A de Magistris, Maria Santucci
%A Di Girolamo, Chiara
%A Lukic, Marko
%A Gram, Inger Torhild
%A Bonet, Catalina
%A Sánchez, Maria-Jose
%A Chirlaque, María-Dolores
%A Amiano, Pilar
%A Guevara, Marcela
%A Vermeulen, Roel
%A Manjer, Jonas
%A Eriksson, Linda
%A Key, Tim J
%A Mayen, Ana-Lucia
%A Dossus, Laure
%A Weiderpass, Elisabete
%A Heath, Alicia K
%A Ferrari, Pietro
%A Jenab, Mazda
%T Alcohol and smoking habits in association with hepatocellular carcinoma risk.
%J International journal of cancer
%V 157
%N 4
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2025-00628
%P 644-657
%D 2025
%Z 2025 Aug 15;157(4):644-657
%X We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case-control subset of 108 HCC cases and 108 matched controls, known biomarkers of smoking (cotinine, nicotine) and habitual alcohol consumption (2-hydroxy-3-methylbutyric acid) were annotated from untargeted metabolomics features. Multivariable-adjusted hazard ratios (HRs) or odds ratios (ORs) with 95
%K biological markers (Other)
%K ethanol (Other)
%K interaction (Other)
%K liver cancer (Other)
%K tobacco (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40098437
%R 10.1002/ijc.35401
%U https://inrepo02.dkfz.de/record/300131