TY  - JOUR
AU  - Aglago, Elom K
AU  - Ramos, Ines
AU  - Keski-Rahkonen, Pekka
AU  - Chatziioannou, Chrysovalantou
AU  - Freisling, Heinz
AU  - Fedirko, Veronika
AU  - Gunter, Marc J
AU  - Dahm, Christina C
AU  - Langmann, Fie
AU  - Bondonno, Nicola
AU  - Tjønneland, Anne
AU  - Severi, Gianluca
AU  - Truong, Therese
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Bergmann, Manuela
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Pala, Valeria
AU  - de Magistris, Maria Santucci
AU  - Di Girolamo, Chiara
AU  - Lukic, Marko
AU  - Gram, Inger Torhild
AU  - Bonet, Catalina
AU  - Sánchez, Maria-Jose
AU  - Chirlaque, María-Dolores
AU  - Amiano, Pilar
AU  - Guevara, Marcela
AU  - Vermeulen, Roel
AU  - Manjer, Jonas
AU  - Eriksson, Linda
AU  - Key, Tim J
AU  - Mayen, Ana-Lucia
AU  - Dossus, Laure
AU  - Weiderpass, Elisabete
AU  - Heath, Alicia K
AU  - Ferrari, Pietro
AU  - Jenab, Mazda
TI  - Alcohol and smoking habits in association with hepatocellular carcinoma risk.
JO  - International journal of cancer
VL  - 157
IS  - 4
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2025-00628
SP  - 644-657
PY  - 2025
N1  - 2025 Aug 15;157(4):644-657
AB  - We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case-control subset of 108 HCC cases and 108 matched controls, known biomarkers of smoking (cotinine, nicotine) and habitual alcohol consumption (2-hydroxy-3-methylbutyric acid) were annotated from untargeted metabolomics features. Multivariable-adjusted hazard ratios (HRs) or odds ratios (ORs) with 95
KW  - biological markers (Other)
KW  - ethanol (Other)
KW  - interaction (Other)
KW  - liver cancer (Other)
KW  - tobacco (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40098437
DO  - DOI:10.1002/ijc.35401
UR  - https://inrepo02.dkfz.de/record/300131
ER  -