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000300141 245__ $$aBovine Meat and Milk Factor (BMMF) Protein Is Expressed in Macrophages Spread Widely over the Mucosa of Colorectal Cancer Patients.
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000300141 520__ $$aRed meat consumption is considered a risk factor for colorectal cancer (CRC) development and stimulated isolation of plasmid-like DNA molecules from bovine serum and milk, termed bovine meat and milk factors (BMMFs). BMMFs encode a conserved replication protein (Rep). Increased populations of Rep-expressing macrophages have been identified in the peritumor of CRC patients and pre-cancerous tissues when compared to the tissues of healthy individuals. This supports the concept that BMMFs increase cancer risk by indirect carcinogenesis, upon induction of chronic inflammation. However, the spread of Rep+ immune cells in tissues at greater distances from primary tumors has not yet been assessed. Here, we immunohistologically analyzed the presence of Rep+ immune cells in sets of tumor, peritumor and, additionally, distant tissues of CRC patients (n = 13). We identified consistently high numbers of BMMF-positive macrophages in mucosal tissues at distances of as much as 25 cm away from the primary tumors, at levels comparable to peritumors and associated with M2-like macrophage polarization. The broad distribution of BMMFs suggests that BMMF+ macrophages might already exist at stages of pre-cancerous dysplasia or before. Quantification of BMMF tissue expression during colonoscopy might help to preventively stratify individuals at risk of developing polyps/CRC and recommend them for enhanced surveillance and/or changes in dietary lifestyle.
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000300141 650_7 $$2Other$$abovine meat and milk factors
000300141 650_7 $$2Other$$achronic inflammation
000300141 650_7 $$2Other$$acolorectal cancer
000300141 650_7 $$2Other$$adiet
000300141 650_7 $$2Other$$aindirect carcinogenesis
000300141 650_7 $$2Other$$amacrophages
000300141 650_7 $$2Other$$amyeloid immune checkpoint
000300141 650_2 $$2MeSH$$aColorectal Neoplasms: metabolism
000300141 650_2 $$2MeSH$$aColorectal Neoplasms: pathology
000300141 650_2 $$2MeSH$$aHumans
000300141 650_2 $$2MeSH$$aMacrophages: metabolism
000300141 650_2 $$2MeSH$$aAnimals
000300141 650_2 $$2MeSH$$aCattle
000300141 650_2 $$2MeSH$$aFemale
000300141 650_2 $$2MeSH$$aMale
000300141 650_2 $$2MeSH$$aMiddle Aged
000300141 650_2 $$2MeSH$$aAged
000300141 650_2 $$2MeSH$$aIntestinal Mucosa: metabolism
000300141 650_2 $$2MeSH$$aIntestinal Mucosa: pathology
000300141 7001_ $$0P:(DE-He78)83275dace99f5b3d2c745bae4297121c$$aNikitina, Ekaterina$$b1$$eFirst author
000300141 7001_ $$0P:(DE-He78)8757fd490dcfe2d6c4b1c2b126262468$$aRahbari, Mohammad$$b2$$udkfz
000300141 7001_ $$0P:(DE-He78)e228057961cd499cd6acd0ce04076f77$$aErnst, Claudia$$b3$$udkfz
000300141 7001_ $$0P:(DE-He78)2214defe87d04a849413e5eed47c415e$$aKrunic, Damir$$b4$$udkfz
000300141 7001_ $$00000-0002-0338-3727$$aBirgin, Emrullah$$b5
000300141 7001_ $$0P:(DE-He78)44a33c775d0e27db79f8fd9e97a99e0a$$aTessmer, Claudia$$b6$$udkfz
000300141 7001_ $$0P:(DE-He78)0c4543046185361a644540fee0dad8b1$$aHofmann, Ilse$$b7$$udkfz
000300141 7001_ $$aRahbari, Nuh$$b8
000300141 7001_ $$0P:(DE-He78)42946c81b039c802769d91e486a4d5fb$$aBund, Timo$$b9$$eFirst author$$udkfz
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