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000300158 0247_ $$2doi$$a10.1002/mp.17786
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000300158 1001_ $$0P:(DE-He78)d51f2b979a3118c75aba4dc5a79247f8$$aMetzner, Margareta$$b0$$eFirst author$$udkfz
000300158 245__ $$aAccuracy of a helium-beam radiography system based on thin pixel detectors for an anthropomorphic head phantom.
000300158 260__ $$aHoboken, NJ$$bWiley$$c2025
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000300158 500__ $$a#EA:E040#LA:E040# / 2025 Jun;52(6):4757-4768
000300158 520__ $$aIon-beam radiography is a promising technique to verify the range of ion-beam radiotherapy treatments regularly. To detect and quantify the water-equivalent thickness (WET) of potential anatomical changes, ion-beam radiographs must provide a sufficient WET accuracy on the level of 1%.In this work, we show an energy-painted helium-beam radiograph of an anthropomorphic head phantom acquired with thin silicon pixel detectors for the first time. Furthermore, we determine the WET accuracy of our helium-beam radiography system for the especially heterogeneous skull base region, which is highly relevant for the treatment of head and neck and skull base tumors.With a detection system based on pixelated semiconducting Timepix detectors, we track single ions upstream and downstream of the head phantom. Furthermore, we measure their energy deposition in a thin Timepix detector behind the anthropomorphic phantom. To ensure a high precision of the image, we acquired a radiograph by using helium beams with five initial energies between 146.84 and 188.07 MeV/u following the energy painting algorithm. With a Siemens SOMATOM Confidence CT scanner, a single- and dual-energy CT were acquired with clinical protocols and translated to relative stopping power (RSP) values. After projecting these scans, the resulting WET maps were compared to the helium-beam radiograph. To evaluate the accuracy of all three modalities, a reference data set based on range-pullback measurements and a segmentation of a high-resolution CT scan was taken into account.The mean absolute percentage error (MAPE) of all modalities was determined to be between 0.95% and 1.16%. Also, the root-mean-square percentage error (RMSPE) was similar for all modalities ranging from 1.19% to 1.46%. These deviations from the reference scan were found to mainly stem from an overestimation of air and sinus tissue and underestimation of cortical bone.The helium-beam radiograph was shown to achieve a WET accuracy competitive with that of clinically used imaging methods. If certain technical aspects are addressed, helium-beam radiography may emerge as an auspicious imaging modality for on-couch range verification of ion-beam radiotherapy treatments allowing for regular detection and quantification of anatomical changes.
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000300158 650_7 $$2Other$$aion‐beam imaging
000300158 650_7 $$2Other$$aproton therapy
000300158 650_7 $$2Other$$atimepix detectors
000300158 7001_ $$0P:(DE-He78)b46c11295b94a94d71c0d912fc1b858f$$aLongarino, Friderike K$$b1$$udkfz
000300158 7001_ $$aAckermann, Benjamin$$b2
000300158 7001_ $$0P:(DE-He78)f0fb397c67acc1650274160f9a19a4fb$$aSchlechter, Annika$$b3$$udkfz
000300158 7001_ $$0P:(DE-He78)38e50f03da97b987bf94f50627b93185$$aSaphörster, Maike$$b4$$udkfz
000300158 7001_ $$0P:(DE-He78)a9882536bb1aef3460dc0bab502d0805$$aXu, Yanting$$b5
000300158 7001_ $$0P:(DE-He78)79cb3d08db060ae75e7e080ba6be6e8a$$aSchlecker, Julian$$b6$$udkfz
000300158 7001_ $$aWohlfahrt, Patrick$$b7
000300158 7001_ $$0P:(DE-HGF)0$$aRichter, Christian$$b8
000300158 7001_ $$aBrons, Stephan$$b9
000300158 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b10$$udkfz
000300158 7001_ $$0P:(DE-He78)440a3f62ea9ea5c63375308976fc4c44$$aJäkel, Oliver$$b11$$udkfz
000300158 7001_ $$0P:(DE-He78)dfe82ba00edb8b1609794fbe37bd616f$$aMartišíková, Mária$$b12$$udkfz
000300158 7001_ $$0P:(DE-He78)4af90cacc534bcab08c5a70badbb2d5e$$aGehrke, Tim$$b13$$eLast author$$udkfz
000300158 773__ $$0PERI:(DE-600)1466421-5$$aDOI:10.1002/mp.17786$$n6$$p4757-4768$$tMedical physics$$v52$$x0094-2405$$y2025
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