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@ARTICLE{Betzler:300163,
      author       = {J. Betzler$^*$ and N. Wiegand and A. Kantorez and A. Finze
                      and S. Schölch$^*$ and C. Reißfelder and M. Otto and S.
                      Blank},
      title        = {{A}ntireflux {S}urgery in {P}atients with {M}oderate
                      {O}besity - {F}undoplication or {R}oux-en-{Y} {G}astric
                      {B}ypass?},
      journal      = {Obesity surgery},
      volume       = {35},
      number       = {5},
      issn         = {0960-8923},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {DKFZ-2025-00649},
      pages        = {1750-1760},
      year         = {2025},
      note         = {#EA:B440# / 2025 May;35(5):1750-1760},
      abstract     = {Gastroesophageal reflux disease (GERD), often associated
                      with obesity, impairs quality of life and can lead to
                      complications. This study compared Fundoplication and
                      Roux-en-Y Gastric Bypass (RYGB) in patients with WHO (World
                      Health Organization) class I and II obesity and refractory
                      GERD.A single-center, retrospective study analyzed 93
                      patients (55 Fundoplication, 38 RYGB) with BMI < 40 kg/m2
                      who underwent surgery between January 2018 and September
                      2021. Preoperative characteristics, surgical outcomes, and
                      postoperative results after three months and after one year
                      were analyzed. Quality of life was assessed using Bariatric
                      Quality of Life (BQL) and Quality of Life in Reflux and
                      Dispepsia (QOLRAD) questionnaires. Propensity-score matching
                      (PSM) was performed using the parameters age, BMI and
                      gender.Patients who underwent RYGB had higher preoperative
                      BMI (35.9 vs. 27.5 kg/m2, p < 0.0001) and more metabolic
                      comorbidities. Patients who underwent Fundoplication
                      experienced longer anesthesia (192.5 vs. 112 min, p <
                      0.0001), operation times (134 vs. 79 min, p < 0.0001), and
                      hospital stays (4 vs. 3 days, p = 0.0003). Complication
                      rates in general (p = 0.0154, after three months) and
                      dysphagia rates in particular (p = 0.0036, after three
                      months and p = 0.0147, after one year) were higher in the
                      Fundoplication group. Preoperatively, patients undergoing
                      RYGB reported poorer quality of life in BQL questionnaires
                      (p = 0.0008). PSM showed less reflux regression in the
                      Fundoplication group after three months (p = 0.0223).Despite
                      higher preoperative BMI and comorbidities, patients
                      undergoing RYGB had shorter operative times and hospital
                      stays. The results suggest RYGB may be preferable for
                      patients with refractory GERD and class I and II obesity,
                      but further research on long-term outcomes is needed.},
      keywords     = {Antireflux surgery (Other) / Fundoplication (Other) / GERD
                      (Other) / Moderate obesity (Other) / RYGB (Other)},
      cin          = {B440 / A430},
      ddc          = {610},
      cid          = {I:(DE-He78)B440-20160331 / I:(DE-He78)A430-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40140136},
      doi          = {DOI:10.1007/s11695-025-07829-1},
      url          = {https://inrepo02.dkfz.de/record/300163},
}