%0 Journal Article
%A Schmitt, Maxime
%A Bohnenberger, Hanibal
%A Bartsch, Detlef Klaus
%A Wagner, Daniel-Christoph
%A Litmeyer, Anne-Sophie
%A Grass, Albert
%A Rinke, Anja
%A Koch, Christine
%A Kremer, Marcus
%A Evert, Matthias
%A Märkl, Bruno
%A Quaas, Alexander
%A Eckstein, Markus
%A Steinestel, Konrad
%A Denkert, Carsten
%A Steiger, Katja
%A Klöppel, Günter
%A Kasajima, Atsuko
%A Tschurtschenthaler, Markus
%A Foersch, Sebastian
%A Jesinghaus, Moritz
%T DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms.
%J Endocrine pathology
%V 36
%N 1
%@ 1046-3976
%C New York, NY
%I Springer
%M DKFZ-2025-00653
%P 9
%D 2025
%X Delta-like ligand 3 (DLL3) is frequently expressed in pulmonary small cell neuroendocrine carcinoma (SCNEC) and has emerged as a promising therapeutic target. However, limited data on DLL3 expression in other neuroendocrine neoplasms (NEN), such as extrapulmonary SCNEC, large cell neuroendocrine carcinomas (LCNEC), mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN), gastroenteropancreatic neuroendocrine tumours (GEP-NET), and pulmonary carcinoids, impedes an estimation if other types of NEN might be suitable candidates for anti-DLL3 therapies. We evaluated DLL3 expression in 1294 NEN and 479 non-neuroendocrine carcinomas, correlating the findings with histological subtypes, tumour localisation, and overall survival (OS). Furthermore, we explored the concordance of DLL3 expression during metastatic progression in 67 paired primary NEN and metastases. DLL3 expression was significantly higher in NEC (64.0
%K Humans
%K Neuroendocrine Tumors: pathology
%K Neuroendocrine Tumors: metabolism
%K Neuroendocrine Tumors: mortality
%K Carcinoma, Neuroendocrine: pathology
%K Carcinoma, Neuroendocrine: metabolism
%K Carcinoma, Neuroendocrine: mortality
%K Lung Neoplasms: pathology
%K Lung Neoplasms: metabolism
%K Male
%K Female
%K Intracellular Signaling Peptides and Proteins: metabolism
%K Intracellular Signaling Peptides and Proteins: biosynthesis
%K Middle Aged
%K Aged
%K Membrane Proteins: metabolism
%K Membrane Proteins: biosynthesis
%K Biomarkers, Tumor: analysis
%K Biomarkers, Tumor: metabolism
%K Adult
%K Cohort Studies
%K Aged, 80 and over
%K DLL3 (Other)
%K Neuroendocrine carcinoma (Other)
%K Neuroendocrine neoplasms (Other)
%K Neuroendocrine tumour (Other)
%K DLL3 protein, human (NLM Chemicals)
%K Intracellular Signaling Peptides and Proteins (NLM Chemicals)
%K Membrane Proteins (NLM Chemicals)
%K Biomarkers, Tumor (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40153138
%R 10.1007/s12022-025-09854-3
%U https://inrepo02.dkfz.de/record/300176