TY  - JOUR
AU  - Schmitt, Maxime
AU  - Bohnenberger, Hanibal
AU  - Bartsch, Detlef Klaus
AU  - Wagner, Daniel-Christoph
AU  - Litmeyer, Anne-Sophie
AU  - Grass, Albert
AU  - Rinke, Anja
AU  - Koch, Christine
AU  - Kremer, Marcus
AU  - Evert, Matthias
AU  - Märkl, Bruno
AU  - Quaas, Alexander
AU  - Eckstein, Markus
AU  - Steinestel, Konrad
AU  - Denkert, Carsten
AU  - Steiger, Katja
AU  - Klöppel, Günter
AU  - Kasajima, Atsuko
AU  - Tschurtschenthaler, Markus
AU  - Foersch, Sebastian
AU  - Jesinghaus, Moritz
TI  - DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms.
JO  - Endocrine pathology
VL  - 36
IS  - 1
SN  - 1046-3976
CY  - New York, NY
PB  - Springer
M1  - DKFZ-2025-00653
SP  - 9
PY  - 2025
AB  - Delta-like ligand 3 (DLL3) is frequently expressed in pulmonary small cell neuroendocrine carcinoma (SCNEC) and has emerged as a promising therapeutic target. However, limited data on DLL3 expression in other neuroendocrine neoplasms (NEN), such as extrapulmonary SCNEC, large cell neuroendocrine carcinomas (LCNEC), mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN), gastroenteropancreatic neuroendocrine tumours (GEP-NET), and pulmonary carcinoids, impedes an estimation if other types of NEN might be suitable candidates for anti-DLL3 therapies. We evaluated DLL3 expression in 1294 NEN and 479 non-neuroendocrine carcinomas, correlating the findings with histological subtypes, tumour localisation, and overall survival (OS). Furthermore, we explored the concordance of DLL3 expression during metastatic progression in 67 paired primary NEN and metastases. DLL3 expression was significantly higher in NEC (64.0
KW  - Humans
KW  - Neuroendocrine Tumors: pathology
KW  - Neuroendocrine Tumors: metabolism
KW  - Neuroendocrine Tumors: mortality
KW  - Carcinoma, Neuroendocrine: pathology
KW  - Carcinoma, Neuroendocrine: metabolism
KW  - Carcinoma, Neuroendocrine: mortality
KW  - Lung Neoplasms: pathology
KW  - Lung Neoplasms: metabolism
KW  - Male
KW  - Female
KW  - Intracellular Signaling Peptides and Proteins: metabolism
KW  - Intracellular Signaling Peptides and Proteins: biosynthesis
KW  - Middle Aged
KW  - Aged
KW  - Membrane Proteins: metabolism
KW  - Membrane Proteins: biosynthesis
KW  - Biomarkers, Tumor: analysis
KW  - Biomarkers, Tumor: metabolism
KW  - Adult
KW  - Cohort Studies
KW  - Aged, 80 and over
KW  - DLL3 (Other)
KW  - Neuroendocrine carcinoma (Other)
KW  - Neuroendocrine neoplasms (Other)
KW  - Neuroendocrine tumour (Other)
KW  - DLL3 protein, human (NLM Chemicals)
KW  - Intracellular Signaling Peptides and Proteins (NLM Chemicals)
KW  - Membrane Proteins (NLM Chemicals)
KW  - Biomarkers, Tumor (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40153138
DO  - DOI:10.1007/s12022-025-09854-3
UR  - https://inrepo02.dkfz.de/record/300176
ER  -