%0 Journal Article
%A Moser, Ismael
%A Engelhardt, Melina
%A Grittner, Ulrike
%A Ferreira, Felipe Monte Santo Regino
%A Denker, Maren
%A Reinsch, Jennifer
%A Fischer, Lisa
%A Link, Tilman
%A Heppner, Frank L
%A Capper, David
%A Vajkoczy, Peter
%A Picht, Thomas
%A Rosenstock, Tizian
%T Analysis of Neuronal Excitability Profiles for Motor-Eloquent Brain Tumor Entities Using nTMS in 800 Patients.
%J Cancers
%V 17
%N 6
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2025-00656
%P 935
%D 2025
%X Non-invasive motor mapping with navigated transcranial magnetic stimulation (nTMS) is an established diagnostic tool to identify spatial relationships between functional and tumor areas and to characterize motor excitability. Recently, nTMS has been used to analyze the impact of different brain tumor entities on motor excitability. However, entity-specific excitability patterns are not sufficiently validated yet.We retrospectively analyzed nTMS motor mapping data of 800 motor-eloquent brain tumor patients in this observational study. The motor excitability profile consisted of four nTMS parameters (resting motor threshold (RMT), cortical motor area, amplitude and latency) measured on both hemispheres. The relationship between motor excitability parameters and tumor entity, glioma subtype and motor status were assessed using multiple regressions analyses. Regression models included patient- and tumor-specific factors.Gliomas had more frequent pathologic RMT ratios (OR 1.76, 95
%K brain tumor (Other)
%K corticospinal tract (Other)
%K glioma (Other)
%K motor cortex (Other)
%K motor evoked potential (Other)
%K motor excitability (Other)
%K navigated transcranial magnetic stimulation (Other)
%K neuroplasticity (Other)
%K resting motor threshold (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40149270
%2 pmc:PMC11940777
%R 10.3390/cancers17060935
%U https://inrepo02.dkfz.de/record/300179