TY  - JOUR
AU  - Moser, Ismael
AU  - Engelhardt, Melina
AU  - Grittner, Ulrike
AU  - Ferreira, Felipe Monte Santo Regino
AU  - Denker, Maren
AU  - Reinsch, Jennifer
AU  - Fischer, Lisa
AU  - Link, Tilman
AU  - Heppner, Frank L
AU  - Capper, David
AU  - Vajkoczy, Peter
AU  - Picht, Thomas
AU  - Rosenstock, Tizian
TI  - Analysis of Neuronal Excitability Profiles for Motor-Eloquent Brain Tumor Entities Using nTMS in 800 Patients.
JO  - Cancers
VL  - 17
IS  - 6
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-00656
SP  - 935
PY  - 2025
AB  - Non-invasive motor mapping with navigated transcranial magnetic stimulation (nTMS) is an established diagnostic tool to identify spatial relationships between functional and tumor areas and to characterize motor excitability. Recently, nTMS has been used to analyze the impact of different brain tumor entities on motor excitability. However, entity-specific excitability patterns are not sufficiently validated yet.We retrospectively analyzed nTMS motor mapping data of 800 motor-eloquent brain tumor patients in this observational study. The motor excitability profile consisted of four nTMS parameters (resting motor threshold (RMT), cortical motor area, amplitude and latency) measured on both hemispheres. The relationship between motor excitability parameters and tumor entity, glioma subtype and motor status were assessed using multiple regressions analyses. Regression models included patient- and tumor-specific factors.Gliomas had more frequent pathologic RMT ratios (OR 1.76, 95
KW  - brain tumor (Other)
KW  - corticospinal tract (Other)
KW  - glioma (Other)
KW  - motor cortex (Other)
KW  - motor evoked potential (Other)
KW  - motor excitability (Other)
KW  - navigated transcranial magnetic stimulation (Other)
KW  - neuroplasticity (Other)
KW  - resting motor threshold (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40149270
C2  - pmc:PMC11940777
DO  - DOI:10.3390/cancers17060935
UR  - https://inrepo02.dkfz.de/record/300179
ER  -