%0 Journal Article
%A Schoeps, Benjamin
%A Lauer, Ulrich M
%A Elbers, Knut
%T Deciphering permissivity of human tumor ecosystems to oncolytic viruses.
%J Oncogene
%V 44
%N 16
%@ 0950-9232
%C London
%I Springer Nature
%M DKFZ-2025-00658
%P 1069-1077
%D 2025
%Z 2025 May;44(16):1069-1077
%X Effective cancer therapy involves initiation of a tumor-specific immune response. Consequently, the interest in oncolytic viruses (OV) capable of triggering immunogenic cell death has sparked in recent years. However, the common use of pre-clinical models that fail to mirror patient tumor ecosystems (TES) hinders clinical translation. Here, we provide a condensed view on the intricate interplay between several aspects of TES and OV action and discuss these considerations in the view of recently developed pre-clinical human model systems. Given the urgent demand for innovative cancer treatments, the purpose of this review is to highlight the so-far overlooked complex impact of the tumor microenvironment (TME) on OV permissivity, with the intent to provide a foundation for future, more effective pre-clinical studies.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40148688
%R 10.1038/s41388-025-03357-5
%U https://inrepo02.dkfz.de/record/300181