TY  - JOUR
AU  - Schoeps, Benjamin
AU  - Lauer, Ulrich M
AU  - Elbers, Knut
TI  - Deciphering permissivity of human tumor ecosystems to oncolytic viruses.
JO  - Oncogene
VL  - 44
IS  - 16
SN  - 0950-9232
CY  - London
PB  - Springer Nature
M1  - DKFZ-2025-00658
SP  - 1069-1077
PY  - 2025
N1  - 2025 May;44(16):1069-1077
AB  - Effective cancer therapy involves initiation of a tumor-specific immune response. Consequently, the interest in oncolytic viruses (OV) capable of triggering immunogenic cell death has sparked in recent years. However, the common use of pre-clinical models that fail to mirror patient tumor ecosystems (TES) hinders clinical translation. Here, we provide a condensed view on the intricate interplay between several aspects of TES and OV action and discuss these considerations in the view of recently developed pre-clinical human model systems. Given the urgent demand for innovative cancer treatments, the purpose of this review is to highlight the so-far overlooked complex impact of the tumor microenvironment (TME) on OV permissivity, with the intent to provide a foundation for future, more effective pre-clinical studies.
LB  - PUB:(DE-HGF)16
C6  - pmid:40148688
DO  - DOI:10.1038/s41388-025-03357-5
UR  - https://inrepo02.dkfz.de/record/300181
ER  -