% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schoeps:300181,
      author       = {B. Schoeps and U. M. Lauer$^*$ and K. Elbers},
      title        = {{D}eciphering permissivity of human tumor ecosystems to
                      oncolytic viruses.},
      journal      = {Oncogene},
      volume       = {44},
      number       = {16},
      issn         = {0950-9232},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-00658},
      pages        = {1069-1077},
      year         = {2025},
      note         = {2025 May;44(16):1069-1077},
      abstract     = {Effective cancer therapy involves initiation of a
                      tumor-specific immune response. Consequently, the interest
                      in oncolytic viruses (OV) capable of triggering immunogenic
                      cell death has sparked in recent years. However, the common
                      use of pre-clinical models that fail to mirror patient tumor
                      ecosystems (TES) hinders clinical translation. Here, we
                      provide a condensed view on the intricate interplay between
                      several aspects of TES and OV action and discuss these
                      considerations in the view of recently developed
                      pre-clinical human model systems. Given the urgent demand
                      for innovative cancer treatments, the purpose of this review
                      is to highlight the so-far overlooked complex impact of the
                      tumor microenvironment (TME) on OV permissivity, with the
                      intent to provide a foundation for future, more effective
                      pre-clinical studies.},
      subtyp        = {Review Article},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40148688},
      doi          = {10.1038/s41388-025-03357-5},
      url          = {https://inrepo02.dkfz.de/record/300181},
}