%0 Journal Article
%A Chelariu-Raicu, Anca
%A Vu, Thanh Chung
%A Umamaheswaran, Sujanitha
%A Stur, Elaine
%A Hanjra, Pahul
%A Han, Yunah
%A Hu, Min
%A Lin, Jerome
%A Lawson, Barrett C
%A Liu, Jinsong
%A Sood, Anil K
%A Wen, Yunfei
%T IMGN853 Induces Autophagic Cell Death in Combination Therapy for Ovarian Cancer.
%J Cancer research communications
%V 5
%N 3
%@ 2767-9764
%C Philadelphia, Pa.
%I American Association for Cancer Research
%M DKFZ-2025-00659
%P 512 - 526
%D 2025
%X FOLR1 is heterogeneously overexpressed in epithelial ovarian cancer. We examined the combined effects of the anti-FOLR1 antibody-drug conjugate (IMGN853) with other drugs, including topotecan, anti-VEGF-A antibody, and olaparib. These findings could contribute to the continued development of IMGN853 in the treatment of ovarian cancer.
%K Female
%K Humans
%K Ovarian Neoplasms: drug therapy
%K Ovarian Neoplasms: pathology
%K Autophagy: drug effects
%K Immunoconjugates: therapeutic use
%K Immunoconjugates: pharmacology
%K Antineoplastic Combined Chemotherapy Protocols: pharmacology
%K Antineoplastic Combined Chemotherapy Protocols: therapeutic use
%K Cell Line, Tumor
%K Piperazines: pharmacology
%K Piperazines: therapeutic use
%K Piperazines: administration & dosage
%K Carcinoma, Ovarian Epithelial: drug therapy
%K Carcinoma, Ovarian Epithelial: pathology
%K Topotecan: pharmacology
%K Topotecan: therapeutic use
%K Topotecan: administration & dosage
%K Folate Receptor 1: metabolism
%K Folate Receptor 1: genetics
%K Phthalazines: pharmacology
%K Phthalazines: therapeutic use
%K Vascular Endothelial Growth Factor A: metabolism
%K Animals
%K Mice
%K Immunoconjugates (NLM Chemicals)
%K olaparib (NLM Chemicals)
%K Piperazines (NLM Chemicals)
%K Topotecan (NLM Chemicals)
%K Folate Receptor 1 (NLM Chemicals)
%K Phthalazines (NLM Chemicals)
%K FOLR1 protein, human (NLM Chemicals)
%K Vascular Endothelial Growth Factor A (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40029935
%2 pmc:PMC11951858
%R 10.1158/2767-9764.CRC-24-0215
%U https://inrepo02.dkfz.de/record/300182