TY  - JOUR
AU  - Chelariu-Raicu, Anca
AU  - Vu, Thanh Chung
AU  - Umamaheswaran, Sujanitha
AU  - Stur, Elaine
AU  - Hanjra, Pahul
AU  - Han, Yunah
AU  - Hu, Min
AU  - Lin, Jerome
AU  - Lawson, Barrett C
AU  - Liu, Jinsong
AU  - Sood, Anil K
AU  - Wen, Yunfei
TI  - IMGN853 Induces Autophagic Cell Death in Combination Therapy for Ovarian Cancer.
JO  - Cancer research communications
VL  - 5
IS  - 3
SN  - 2767-9764
CY  - Philadelphia, Pa.
PB  - American Association for Cancer Research
M1  - DKFZ-2025-00659
SP  - 512 - 526
PY  - 2025
AB  - FOLR1 is heterogeneously overexpressed in epithelial ovarian cancer. We examined the combined effects of the anti-FOLR1 antibody-drug conjugate (IMGN853) with other drugs, including topotecan, anti-VEGF-A antibody, and olaparib. These findings could contribute to the continued development of IMGN853 in the treatment of ovarian cancer.
KW  - Female
KW  - Humans
KW  - Ovarian Neoplasms: drug therapy
KW  - Ovarian Neoplasms: pathology
KW  - Autophagy: drug effects
KW  - Immunoconjugates: therapeutic use
KW  - Immunoconjugates: pharmacology
KW  - Antineoplastic Combined Chemotherapy Protocols: pharmacology
KW  - Antineoplastic Combined Chemotherapy Protocols: therapeutic use
KW  - Cell Line, Tumor
KW  - Piperazines: pharmacology
KW  - Piperazines: therapeutic use
KW  - Piperazines: administration & dosage
KW  - Carcinoma, Ovarian Epithelial: drug therapy
KW  - Carcinoma, Ovarian Epithelial: pathology
KW  - Topotecan: pharmacology
KW  - Topotecan: therapeutic use
KW  - Topotecan: administration & dosage
KW  - Folate Receptor 1: metabolism
KW  - Folate Receptor 1: genetics
KW  - Phthalazines: pharmacology
KW  - Phthalazines: therapeutic use
KW  - Vascular Endothelial Growth Factor A: metabolism
KW  - Animals
KW  - Mice
KW  - Immunoconjugates (NLM Chemicals)
KW  - olaparib (NLM Chemicals)
KW  - Piperazines (NLM Chemicals)
KW  - Topotecan (NLM Chemicals)
KW  - Folate Receptor 1 (NLM Chemicals)
KW  - Phthalazines (NLM Chemicals)
KW  - FOLR1 protein, human (NLM Chemicals)
KW  - Vascular Endothelial Growth Factor A (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40029935
C2  - pmc:PMC11951858
DO  - DOI:10.1158/2767-9764.CRC-24-0215
UR  - https://inrepo02.dkfz.de/record/300182
ER  -