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@ARTICLE{deJager:300187,
      author       = {V. D. de Jager and P. Giacomini and J. A. Fairley and R. A.
                      Toledo and S. J. Patton and S. A. Joosse and C. Koch and Z.
                      C. Deans and K. Pantel and E. Heitzer and E. Schuuring},
      collaboration = {E. c. W. Group},
      othercontributors = {S. Agelaki and C. L. Andersen and D. Andersson and B.
                          Bellosillo and I. R. Bergheim and D. van den Broek and Z. C.
                          Deans and E. Dequeker and J. A. Fairley and B. García
                          Peláez and P. Giacomini and A. Greystoke and A. Hallermayr
                          and E. Heitzer and T. J. N. Hiltermann and M. Hubank and S.
                          Indraccolo and V. D. de Jager and S. A. Joosse and L. Keller
                          and M. Krebs and M. Ligtenberg and L. Lo Cascio and M. A.
                          Molina-Vila and K. Nahlik and M. Neumaier and B. Nowack and
                          A. Oniscu and S. Ossowski and A. Oszwald and N. Pallisgaard
                          and K. Pantel and S. J. Patton and M. H. Rasmussen and E.
                          Rouleau and A. Roshan and M. Rot and H. Schlecht and E.
                          Schuuring and U. Schüller and L. Silwal-Pandit and H.
                          Sültmann$^*$ and P. Taniere and R. Toledo and N.
                          Wuerdemann},
      title        = {{R}eporting of molecular test results from cell-free {DNA}
                      analyses: expert consensus recommendations from the 2023
                      {E}uropean {L}iquid {B}iopsy {S}ociety ct{DNA} {W}orkshop.},
      journal      = {EBioMedicine},
      volume       = {114},
      issn         = {2352-3964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00664},
      pages        = {105636},
      year         = {2025},
      abstract     = {The implementation of circulating tumor DNA (ctDNA) in the
                      diagnostic routine may enable non-invasive predictive
                      biomarker testing and treatment optimization in patients who
                      lack a suitable tumor specimen, have failed previous
                      molecular analysis or are clinically ineligible for
                      (re-)biopsy procedures. As the interpretation and reporting
                      are more complex for ctDNA than conventional tissue-based
                      NGS, there is a need for specific guidelines. These will
                      offer support for the reporting of ctDNA test results and
                      will facilitate optimal communication of liquid biopsy
                      findings between diagnostic laboratories and the medical
                      oncology team. Aiming to generate guidelines based on
                      real-world experiences and broad perspectives, we organized
                      a European Liquid Biopsy Society (ELBS) ctDNA workshop, in
                      which forty-four experts and key stakeholders from different
                      molecular diagnostics laboratories, oncology and pathology
                      departments, as well as an IVDR specialist, convened to
                      address significant challenges associated with the reporting
                      of liquid biopsy test results. This report delineates the
                      resulting consensus recommendations for ctDNA test reporting
                      with underlying rationale and background information.},
      subtyp        = {Review Article},
      keywords     = {Expert consensus recommendations (Other) / Liquid biopsy
                      (Other) / ctDNA test reporting (Other)},
      cin          = {B063 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B063-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40121940},
      doi          = {10.1016/j.ebiom.2025.105636},
      url          = {https://inrepo02.dkfz.de/record/300187},
}