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@ARTICLE{Hemminki:300188,
      author       = {K. Hemminki$^*$ and F. Zitricky and K. Sundquist and J.
                      Sundquist and A. Försti$^*$ and A. Hemminki},
      title        = {{S}ex specific familial risk in lung cancer through
                      changing histologies in {S}weden.},
      journal      = {International journal of cancer},
      volume       = {157},
      number       = {5},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-00665},
      pages        = {858-866},
      year         = {2025},
      note         = {2025 Sep 1;157(5):858-866},
      abstract     = {Familial clustering of lung cancer (LC) is related to
                      shared smoking habits but the contribution of other
                      potential factors such as sex or histology is not well
                      known, and these are the subjects of the present study in
                      Sweden. Family relationships (from Multigeneration register)
                      and diagnosed cancers (from Cancer registry) were obtained
                      from the national registers from 1961 to 2021. The overall
                      familial risk for LC was constant from the 1990s but the
                      male familial risk decreased while the female familial risk
                      doubled at the same time when female incidence doubled. The
                      female familial risk for mother-daughter pairs was higher
                      (SIR = 2.2 [2.0-2.3], N = 716) than for father-son pairs
                      (SIR = 1.6 [1.5-1.8], N = 962). The histology-specific
                      familial risks for adenocarcinoma, squamous cell carcinoma,
                      small cell and large cell carcinoma were highest for
                      concordant histology but also present for discordant
                      histology. The number of family members diagnosed with LC
                      was a strong determinant of familial risk. The novel results
                      showed that familial risk of LC depends on the background
                      incidence of LC and is higher for women compared to men. We
                      demonstrated further an increased familial risk for each of
                      the four histological types of LC which was higher for
                      concordant than discordant histologies but was even detected
                      between discordant histologies suggesting that LC histology
                      is not a genetic trait.},
      keywords     = {adenocarcinoma (Other) / age of onset (Other) / incidence
                      trend (Other) / proband (Other) / sibling risk (Other)},
      cin          = {Z999 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)Z999-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40156379},
      doi          = {DOI:10.1002/ijc.35431},
      url          = {https://inrepo02.dkfz.de/record/300188},
}