%0 Journal Article
%A Sollier, Etienne
%A Riedel, Anna
%A Toprak, Umut
%A Wierzbinska, Justyna Anna
%A Weichenhan, Dieter
%A Schmid, Jan Philipp
%A Hakobyan, Mariam
%A Touzart, Aurore
%A Jahn, Ekaterina
%A Vick, Binje
%A Brown-Burke, Fiona
%A Kelly, Katherine
%A Kelekci, Simge
%A Pejkovska, Anastasija
%A Goyal, Ashish
%A Bähr, Marion
%A Breuer, Kersten
%A Chen, Mei-Ju
%A Llamazares-Prada, Maria
%A Hartmann, Mark
%A Schönung, Maximilian
%A Correia, Nadia
%A Trumpp, Andreas
%A Abdullah, Yomn
%A Klingmüller, Ursula
%A Mughal, Sadaf Shabbir
%A Brors, Benedikt
%A Westermann, Frank
%A Ulrich, Elias
%A Autry, Robert
%A Schlesner, Matthias
%A Vosberg, Sebastian
%A Herold, Tobias
%A Greif, Philipp
%A Pfeifer, Dietmar
%A Lübbert, Michael
%A Fischer, Thomas
%A Heidel, Florian H
%A Gebhard, Gebhard
%A Walter, Wencke
%A Haferlach, Torsten
%A Eisfeld, Ann-Kathrin
%A Mrózek, Krzysztof
%A Nicolet, Deedra
%A Bullinger, Lars
%A Smeenk, Leonie
%A Erpelinck-Verschueren, Claudia
%A Mulet-Lazaro, Roger
%A Delwel, Ruud
%A Ernst, Aurélie
%A Scherer, Michael
%A Lutsik, Pavlo
%A Jeremias, Irmela
%A Döhner, Konstanze
%A Döhner, Hartmut
%A Lipka, Daniel
%A Plass, Christoph
%T Enhancer hijacking discovery in acute myeloid leukemia by pyjacker identifies MNX1 activation via deletion 7q.
%J Blood cancer discovery
%V 6
%N 4
%@ 2643-3230
%C Philadelphia, PA
%I American Association for Cancer Research
%M DKFZ-2025-00686
%P 343-363
%D 2025
%Z #EA:B370#EA:B087#LA:B370#LA:B340# / 2025 Jul 1;6(4):343-363
%X Acute myeloid leukemia with complex karyotype (ckAML) is characterized by high genomic complexity, including frequent TP53 mutations and chromothripsis. Genomic rearrangements that reposition active enhancers near proto-oncogenes, leading to their aberrant expression, have not been systematically investigated in AML. To facilitate the discovery of such 'enhancer hijacking' events, we developed pyjacker, a computational tool, and applied it to 39 ckAML samples. Pyjacker identified several enhancer hijacking events in AML patient samples, including aberrant expression of motor neuron and pancreas homeobox 1 (MNX1), which can result from del(7)(q22q36) and is associated with hijacking of a CDK6 enhancer. MNX1 activation occurs in 1.4
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40162972
%R 10.1158/2643-3230.BCD-24-0278
%U https://inrepo02.dkfz.de/record/300224