TY  - JOUR
AU  - Sollier, Etienne
AU  - Riedel, Anna
AU  - Toprak, Umut
AU  - Wierzbinska, Justyna Anna
AU  - Weichenhan, Dieter
AU  - Schmid, Jan Philipp
AU  - Hakobyan, Mariam
AU  - Touzart, Aurore
AU  - Jahn, Ekaterina
AU  - Vick, Binje
AU  - Brown-Burke, Fiona
AU  - Kelly, Katherine
AU  - Kelekci, Simge
AU  - Pejkovska, Anastasija
AU  - Goyal, Ashish
AU  - Bähr, Marion
AU  - Breuer, Kersten
AU  - Chen, Mei-Ju
AU  - Llamazares-Prada, Maria
AU  - Hartmann, Mark
AU  - Schönung, Maximilian
AU  - Correia, Nadia
AU  - Trumpp, Andreas
AU  - Abdullah, Yomn
AU  - Klingmüller, Ursula
AU  - Mughal, Sadaf Shabbir
AU  - Brors, Benedikt
AU  - Westermann, Frank
AU  - Ulrich, Elias
AU  - Autry, Robert
AU  - Schlesner, Matthias
AU  - Vosberg, Sebastian
AU  - Herold, Tobias
AU  - Greif, Philipp
AU  - Pfeifer, Dietmar
AU  - Lübbert, Michael
AU  - Fischer, Thomas
AU  - Heidel, Florian H
AU  - Gebhard, Gebhard
AU  - Walter, Wencke
AU  - Haferlach, Torsten
AU  - Eisfeld, Ann-Kathrin
AU  - Mrózek, Krzysztof
AU  - Nicolet, Deedra
AU  - Bullinger, Lars
AU  - Smeenk, Leonie
AU  - Erpelinck-Verschueren, Claudia
AU  - Mulet-Lazaro, Roger
AU  - Delwel, Ruud
AU  - Ernst, Aurélie
AU  - Scherer, Michael
AU  - Lutsik, Pavlo
AU  - Jeremias, Irmela
AU  - Döhner, Konstanze
AU  - Döhner, Hartmut
AU  - Lipka, Daniel
AU  - Plass, Christoph
TI  - Enhancer hijacking discovery in acute myeloid leukemia by pyjacker identifies MNX1 activation via deletion 7q.
JO  - Blood cancer discovery
VL  - 6
IS  - 4
SN  - 2643-3230
CY  - Philadelphia, PA
PB  - American Association for Cancer Research
M1  - DKFZ-2025-00686
SP  - 343-363
PY  - 2025
N1  - #EA:B370#EA:B087#LA:B370#LA:B340# / 2025 Jul 1;6(4):343-363
AB  - Acute myeloid leukemia with complex karyotype (ckAML) is characterized by high genomic complexity, including frequent TP53 mutations and chromothripsis. Genomic rearrangements that reposition active enhancers near proto-oncogenes, leading to their aberrant expression, have not been systematically investigated in AML. To facilitate the discovery of such 'enhancer hijacking' events, we developed pyjacker, a computational tool, and applied it to 39 ckAML samples. Pyjacker identified several enhancer hijacking events in AML patient samples, including aberrant expression of motor neuron and pancreas homeobox 1 (MNX1), which can result from del(7)(q22q36) and is associated with hijacking of a CDK6 enhancer. MNX1 activation occurs in 1.4
LB  - PUB:(DE-HGF)16
C6  - pmid:40162972
DO  - DOI:10.1158/2643-3230.BCD-24-0278
UR  - https://inrepo02.dkfz.de/record/300224
ER  -