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@ARTICLE{Sollier:300224,
      author       = {E. Sollier$^*$ and A. Riedel$^*$ and U. Toprak$^*$ and J.
                      A. Wierzbinska$^*$ and D. Weichenhan$^*$ and J. P.
                      Schmid$^*$ and M. Hakobyan$^*$ and A. Touzart$^*$ and E.
                      Jahn and B. Vick$^*$ and F. Brown-Burke$^*$ and K. Kelly$^*$
                      and S. Kelekci$^*$ and A. Pejkovska$^*$ and A. Goyal$^*$ and
                      M. Bähr$^*$ and K. Breuer$^*$ and M.-J. Chen$^*$ and M.
                      Llamazares-Prada$^*$ and M. Hartmann$^*$ and M.
                      Schönung$^*$ and N. Correia and A. Trumpp and Y.
                      Abdullah$^*$ and U. Klingmüller$^*$ and S. S. Mughal$^*$
                      and B. Brors$^*$ and F. Westermann$^*$ and E. Ulrich$^*$ and
                      R. Autry$^*$ and M. Schlesner and S. Vosberg$^*$ and T.
                      Herold$^*$ and P. Greif$^*$ and D. Pfeifer and M. Lübbert
                      and T. Fischer and F. H. Heidel and G. Gebhard and W. Walter
                      and T. Haferlach and A.-K. Eisfeld and K. Mrózek and D.
                      Nicolet and L. Bullinger and L. Smeenk and C.
                      Erpelinck-Verschueren and R. Mulet-Lazaro and R. Delwel and
                      A. Ernst$^*$ and M. Scherer$^*$ and P. Lutsik$^*$ and I.
                      Jeremias$^*$ and K. Döhner and H. Döhner and D. Lipka$^*$
                      and C. Plass$^*$},
      title        = {{E}nhancer hijacking discovery in acute myeloid leukemia by
                      pyjacker identifies {MNX}1 activation via deletion 7q.},
      journal      = {Blood cancer discovery},
      volume       = {6},
      number       = {4},
      issn         = {2643-3230},
      address      = {Philadelphia, PA},
      publisher    = {American Association for Cancer Research},
      reportid     = {DKFZ-2025-00686},
      pages        = {343-363},
      year         = {2025},
      note         = {#EA:B370#EA:B087#LA:B370#LA:B340# / 2025 Jul
                      1;6(4):343-363},
      abstract     = {Acute myeloid leukemia with complex karyotype (ckAML) is
                      characterized by high genomic complexity, including frequent
                      TP53 mutations and chromothripsis. Genomic rearrangements
                      that reposition active enhancers near proto-oncogenes,
                      leading to their aberrant expression, have not been
                      systematically investigated in AML. To facilitate the
                      discovery of such 'enhancer hijacking' events, we developed
                      pyjacker, a computational tool, and applied it to 39 ckAML
                      samples. Pyjacker identified several enhancer hijacking
                      events in AML patient samples, including aberrant expression
                      of motor neuron and pancreas homeobox 1 (MNX1), which can
                      result from del(7)(q22q36) and is associated with hijacking
                      of a CDK6 enhancer. MNX1 activation occurs in $1.4\%$ of AML
                      patients and shows significant co-occurrence with BCOR
                      mutations. Through a xenograft mouse model, we demonstrated
                      that MNX1 is required for leukemia cell fitness. Pyjacker is
                      an easy-to-use, accurate, and broadly applicable tool for
                      identifying consequences of genomic events driving
                      tumorigenesis, especially when germline genomic data is
                      missing.},
      cin          = {B370 / B087 / MU01 / B340 / B200 / B330 / HD01 / B062 /
                      B420},
      ddc          = {610},
      cid          = {I:(DE-He78)B370-20160331 / I:(DE-He78)B087-20160331 /
                      I:(DE-He78)MU01-20160331 / I:(DE-He78)B340-20160331 /
                      I:(DE-He78)B200-20160331 / I:(DE-He78)B330-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)B420-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40162972},
      doi          = {10.1158/2643-3230.BCD-24-0278},
      url          = {https://inrepo02.dkfz.de/record/300224},
}