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@ARTICLE{Gottschlich:300241,
      author       = {A. Gottschlich$^*$ and R. Grünmeier and G. V. Hoffmann and
                      S. Nandi and V. Kavaka and P. J. Müller and J. Jobst and A.
                      Oner and R. Kaiser and J. Gärtig and I. Piseddu and S.
                      Frenz-Wiessner and S. D. Fairley and H. Schulz and V. Igl
                      and T. A. Janert and L. Di Fina and M. Mulkers and M. Thomas
                      and D. Briukhovetska and D. Simnica and E. Carlini and C. A.
                      Tsiverioti and M. P. Trefny and T. Lorenzini and F. Märkl
                      and P. Mesquita and R. Brabenec and T. Strzalkowski and S.
                      Stock$^*$ and S. Michaelides and J. Hellmuth and M. Thelen
                      and S. Reinke and W. Klapper and P. F. Gelebart and L.
                      Nicolai and C. Marr and E. Beltrán and R. T. A. Megens and
                      C. Klein and F. Baran-Marszak and A. Rosenwald and M. von
                      Bergwelt-Baildon$^*$ and P. J. Bröckelmann and S.
                      Endres$^*$ and S. Kobold$^*$},
      title        = {{D}issection of single-cell landscapes for the development
                      of chimeric antigen receptor {T} cells in {H}odgkin
                      lymphoma.},
      journal      = {Blood},
      volume       = {145},
      number       = {14},
      issn         = {0006-4971},
      address      = {Washington, DC},
      publisher    = {American Society of Hematology},
      reportid     = {DKFZ-2025-00702},
      pages        = {1536-1552},
      year         = {2025},
      note         = {2025 Apr 3;145(14):1536-1552},
      abstract     = {The success of targeted therapies for hematological
                      malignancies has heralded their potential as both salvage
                      treatment and early treatment lines, reducing the need for
                      high-dose, intensive, and often toxic chemotherapeutic
                      regimens. For young patients with classic Hodgkin lymphoma
                      (cHL), immunotherapies provide the possibility to lessen
                      long-term, treatment-related toxicities. However, suitable
                      therapeutic targets are lacking. By integrating single-cell
                      dissection of the tumor landscape and an in-depth,
                      single-cell-based off-tumor antigen prediction, we identify
                      CD86 as a promising therapeutic target in cHL. CD86 is
                      highly expressed on Hodgkin and Reed-Sternberg cancer cells
                      and cHL-specific tumor-associated macrophages. We reveal
                      CD86-CTLA-4 as a key suppressive pathway in cHL, driving
                      T-cell exhaustion. Cellular therapies targeting CD86 had
                      extraordinary efficacy in vitro and in vivo and were safe in
                      immunocompetent mouse models without compromising bacterial
                      host defense in sepsis models. Our results prove the
                      potential value of anti-CD86 immunotherapies for treating
                      cHL.},
      keywords     = {Hodgkin Disease: therapy / Hodgkin Disease: immunology /
                      Hodgkin Disease: pathology / Humans / Animals / Mice /
                      Receptors, Chimeric Antigen: immunology / B7-2 Antigen:
                      immunology / T-Lymphocytes: immunology / Immunotherapy,
                      Adoptive: methods / Single-Cell Analysis / Female / Cell
                      Line, Tumor / Receptors, Chimeric Antigen (NLM Chemicals) /
                      B7-2 Antigen (NLM Chemicals)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40178843},
      doi          = {10.1182/blood.2023022197},
      url          = {https://inrepo02.dkfz.de/record/300241},
}