TY  - JOUR
AU  - Koll, Katja K
AU  - Klevansky, Donna A
AU  - Kasakovski, Dimitri
AU  - Ahmadzadeh, Nima
AU  - Will, Patrick A
AU  - Kneser, Ulrich
AU  - Hirche, Christoph
TI  - Analysis of the (lymph-)angiogenic potential of regenerative scaffolds and the impact of adipose-derived mesenchymal stem cells.
JO  - Plastic and reconstructive surgery
VL  - nn
SN  - 0032-1052
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - DKFZ-2025-00714
SP  - nn
PY  - 2025
N1  - ISSN 1529-4242 /  Division of Vascular Oncology and Metastasis / DKFZ-ZMBH Alliance
AB  - Regenerative matrices are essential in the therapy of complex wounds, where lymphangiogenesis and angiogenesis play crucial roles. This work investigates the lymph- and angiogenic potential of regenerative scaffolds and the influence of adipose-derived mesenchymal stem cells (ADSC) in a rodent wound model.In a wound model, we administered different Acellular Dermal Matrices (ADMs) to two wounds on each rat-enriching one with ADSCs and leaving the other without. ADSCs were isolated from rodent inguinal fat tissue, characterized using FACS, and their viability confirmed in vitro on different matrices. Tissue samples were collected on days 7, 14, 21, and 28 postoperatively. Six different ADMs, including two synthetic and four biological variants, were compared using histological, immunofluorescence staining, and molecular biological analyses.ADM integration varied, with Collagen-Elastin-ADM showing the highest integration (95
KW  - Acellular dermal matrices (Other)
KW  - adipose-derived mesenchymal stem cells (ADSC) (Other)
KW  - angiogenesis (Other)
KW  - lymphangiogenesis (Other)
KW  - scaffolds (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40178869
DO  - DOI:10.1097/PRS.0000000000012131
UR  - https://inrepo02.dkfz.de/record/300253
ER  -